alpinumisoflavone/zhubný nádor

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Alpinumisoflavone Inhibits Tumor Growth and Metastasis in Papillary Thyroid Cancer via Up-regulating miR-141-3p.

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Alpinumisoflavone (AIF) as principal active ingredient of traditional Chinese herb Derris eriocarpa exerts a broad spectrum of anti-cancer activities against solid tumors. However, little is known about the effect of AIF on Papillary Thyroid Cancer (PTC). Objectives of this study are to investigate

Alpinumisoflavone suppresses tumour growth and metastasis of clear-cell renal cell carcinoma.

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Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel

Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.

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OBJECTIVE Colorectal Cancer (CRC) accounts for 6.1% incidence and 9.2% mortality worldwide. The current study aimed to investigate the effect of alpinumisoflavone (AIF) on CRC and its possible molecular mechanism. METHODS HCT-116 and SW480 cells were chosen as cell model to study the anti-cancer

Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells.

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BACKGROUND In medical oncology, multi-drug resistance (MDR) of cancer cells continues to be a major impediment. We are in quest of novel anti-proliferative agents to overcome drug-resistant tumor cells. METHODS In the present study, we investigated the cytotoxicity of 7 naturally occurring phenolic

Alpinumisoflavone Suppresses Human glioblastoma Cell Growth and Induces Cell Cycle Arrest Through Activating Peroxisome Proliferator-Activated Receptor-γ.

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As a common subtype of malignant gliomas, glioblastoma multiforme (GBM) is associated with poor prognosis. This study is aimed to examine the anti-cancer activities of alpinumisoflavone (AIF) and its underlying mechanisms. Our results demonstrated that AIF inhibited the proliferation of GBM cells

Alpinumisoflavone suppresses hepatocellular carcinoma cell growth and metastasis via NLRP3 inflammasome-mediated pyroptosis.

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This research aims to explore the effect of alpinumisoflavone (AIF) as an anti-cancer drug for the treatment of patients with hepatocellular carcinoma (HCC).Cell counting kit-8 (CCK-8) and colony formation assay were used to evaluate the viability of the

Detarium microcarpum, Guiera senegalensis, and Cassia siamea Induce Apoptosis and Cell Cycle Arrest and Inhibit Metastasis on MCF7 Breast Cancer Cells.

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Despite the availability of anticancer drugs, breast cancer remains the most death-causing tumor-related disease in women. Hence, there is a need for discovery and development of efficient alternative drugs, and sources such as plants need to be explored. In this study, antioxidant capacities and

Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways.

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Hypoxia is a common feature of solid tumors, and the extent of tumor hypoxia correlates with advanced disease stages and treatment resistance. The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important tumor-selective molecular target for anticancer drug discovery directed

[Studies on flavonoids from Derris eriocarpa].

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Derris eriocarpa, a traditional Chinese medicine belonging to the family of Leguminosae, is widely distributed mainly over Yunnan, Guangxi and Guizhou of China. Modern pharmacological researches on this herb showed that it had extensive bioactivities, such as promoting urination, removing dampness

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