Instant noodles contained AMP-1915 2 g/pc with meal, 1 pc/day for 3 months.

Instant noodles with the same sharp and color as Experimental noodles with meal, 1 pc/day for 3 months.

Metabolic Syndrome X

A traditional Chinese Formula extract from Astragalus, Radix Puerariae and Cortex Mori is mixed into instant noodles. Patients are treated with AMP-1915 as meal.

AMP-1915

Placebo

Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome

Phase 0 Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome

Patients' FBG from both placebo and AMP-1915-treated group was collected before treatment as a baseline and after 3-month treatment.
The difference between these two time points presents the drug effect.

Patients' blood from both placebo and AMP-1915-treated group was collected before treatment as a baseline and after 3-month treatment. Triglyceride (TG), total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) were measured.
The difference between these two time points presents the drug effect, separately.

Patients' insulin concentration from both placebo and AMP-1915-treated group was collected before treatment as a baseline and after 3-month treatment.
The difference between these two time points presents the drug effect.

Patients' body weight from both placebo and AMP-1915-treated group was measured before treatment as a baseline and after 3-month treatment.
The difference between these two time points presents the drug effect.

Patients' Plasma HbA1c from both placebo and AMP-1915-treated group was measured before treatment as a baseline and after 3-month treatment.
The difference between these two time points presents the drug effect.

Shanghai University of Traditional Chinese Medicine

Subjects in this arm receive high dose (217 g/day) TSD for 16 weeks.

Subjects in this arm receive low dose (69 g/day) TSD for 16 weeks.

Leiomyoma

TSD is composed of 15 individual Chinese medicines: Astragalus Membranaceus, Semen Coicis, Poria, Curcuma longa L, and Fritillaria Thunbergii Miq, Cassia twig, Pollen typhae, Resina draconis, Lithospermum erythrorhizon, Halloysitum Rubrum, Rhizoma Corydalis processed with vinegar, Hirudo, Calcined corrugated sub , Oyster Shell and Laminaria Japonica Aresch.
High dose (127g) or Low dose (69g) TSD decoction boiled as 200ml per bag; 2 bags per day, 6 days per week; Orally in-take one bag of TSD decoction in morning and another in evening after meal; The whole treatment lasts for 16 weeks.

American Society of Reproductive Medicine Patient Booklet: Uterine Fibroids

School of Chinese Medicine, University of Hong Kong

Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids

A Double-blind, Randomized, Two-dose Trial of Tumor-shrinking Decoction (TSD), a Chinese Medicine Preparation in Patients With Symptomatic Uterine Fibroids

UFS-QOL consists of 37 items to assess the severity of UFs-related symptoms and the quality of life of patients.

The secondary clinical outcome is the clinical response that is defined as a ≥30% baseline-to-endpoint reduction on the symptom severity of transformed UFS-QOL score.

Imaging outcomes will be examined at baseline and endpoint using magnetic resonance imaging (MRI) scan to determine the number, size and density of the uterine fibroids.

two blood samples will be collected from each patient at baseline and at the end of the study, respectively. The collection of blood will be conducted between 08:00 and 09:00 before meal. Sera will be separated and stored at -20ºC until assayed. Serum concentrations of estrogen, progesterone and follicle-stimulating hormone will be measured using chemiluminescent immunoassay (CLIA).

Adverse events will be closely monitored at each visit. All adverse events, reported, elicited or observed, will be recorded on case report form, including the date and time of onset, duration, severity, relationship to study drug, and action taken.

The University of Hong Kong

Stroke

Hemorrhagic Transformation Due to Acute Stroke

Astragalus membranaceus ( AM) at a rate of 3 g three times per day

Chinese Herb Astragalus membranaceus

Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke

The primary outcome measures were the differences in patients' scores on several clinical scales, between baseline (within 7 ± 1 days after the onset of stroke) and week 4 (28 ± 4 days), and between at baseline and week 12 (84 ± 10 days). The scales we used were the Functional Independence Measure scale (FIM), Barthel Index scale (BI), Glasgow Outcome Scale (GOS), and Modified Rankin Scale (MRS). The scores of FIM, BI, GOS, and MRS were assessed by an experienced research nurse.

inflammatory index, which included the levels of C-reactive protein (CRP) and erythrocyte sediment rate (ESR) for venous blood; these were measured at baseline (prior to the first AM dose), and again on the fourth and seventh day of admission; and
Computer tomography (CT) examination, which was done at baseline and on the fourth and seventh days of admission. The ratio of brain edema was calculated by CT (volume of edema divided by blood clot volume)

astragalus melilotoides/protiplesňový

Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome

Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids

Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke

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