The present invention provides novel phenylaminoalkyl-carboxylic acid derivatives represented by the general formula: ##STR1##(wherein R.sup.1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, an alicyclic amino group or a mono or di(lower alkyl)amino group which may have a hydroxy group or a lower alkoxy group as a substituent; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom or a halogen atom; R.sup.4 and R.sup.5 are the same or different and each represents a hydrogen atom, a halogen atom or a lower alkyl group; A represents a lower alkylene group; the carbon atom marked with (R) represents a carbon atom in (R) configuration; and the carbon atom marked with (S) represents a carbon atom in (S) configuration) and pharmaceutically acceptable salts thereof, which have excellent .beta..sub.3 -adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

Kissei Pharmaceutical Co., Ltd.

Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same

The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: ##STR1##(wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent .beta..sub.3 -adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.

2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same

The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: ##STR1##(wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R.sup.2 represents a hydrogen atom a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent .beta..sub.3 -adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.

2-Methylpropionic acid derivatives and medicinal compositions containing the same

The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: ##STR1##wherein R.sup.1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino group; one of R.sup.2 and R.sup.3 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, while the other is a hydrogen atom; R.sup.4 represents a halogen atom, a lower alkyl group, a halo(lower alkyl) group, a hydroxy group, a lower alkoxy group, an aralkoxy group, a cyano group, a nitro group, an amino group, a mono or di(lower alkyl)amino group, a carbamoyl group, a mono or di(lower alkyl)carbamoyl group or a group represented by the general formula:(wherein R.sup.5 represents a hydrogen atom or a lower alkyl group); the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration, and pharmaceutically acceptable salts thereof, which have excellent .beta..sub.3 -adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

calculi/obezita

Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same

2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same

2-Methylpropionic acid derivatives and medicinal compositions containing the same

Phenoxyacetic acid derivatives and medicinal compositions containing the same

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