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Strana 1 od 23 výsledky
Assay for identifying agents which act on the ceramide-activated protein kinase, kinase suppressor of ras, and methods of using said agents
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Throughout this application, various publications are referenced by Arabic numerals. Full citations for these references may be found at the end of the specification immediately preceding the claims. The disclosure of these publications is hereby incorporated by reference into this application to
Compounds for inhibition of ceramide-mediated signal transduction
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to compounds effective in modulating cellular responses stimulated by ceramide-mediated signal transduction, in particular in response to stimulus by the cytokine tumor necrosis factor .alpha. (TNF-.alpha.). More
Anti-ceramide monoclonal antibody 2A2
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention is in the field of methods for treating and preventing GI Syndrome and Graft Versus Host Disease.
2. Description of the Related Art
Radiation remains one of the most effective treatments for a wide variety of malignant cells;
Regulation of human ceramide kinase
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FIELD OF THE INVENTION
The invention relates to the area of regulation of intracellular signaling. More particularly, the invention relates to the regulation of human ceramide kinase activity to increase or decrease intracellular signaling.
BACKGROUND OF THE INVENTION
Human ceramide kinase
Compositions comprising a combination of a free sphingoid base and ceramide and uses thereof
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FIELD OF THE INVENTION
The present invention relates to the field of topical use of compositions comprising a selected combination of sphingolipids.
BACKGROUND OF THE INVENTION
The human skin forms a structural and adapted barrier to the environment. It further plays an important physiological role
Pseudo ceramide compound, and pharmaceutical composition and cosmetic composition comprising same
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CROSS REFERENCE TO RELATED APPLICATIONS
The present application is a U.S. National Phase of International Patent Application Serial No. PCT/KR2014/012726, entitled "NOVEL PSEUDO CERAMIDE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND COSMETIC COMPOSITION COMPRISING SAME," filed on Dec. 23, 2014, which
Lewis-associated compound, process for producing the same, and anti-inflammatory
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This application is filed under 35 U.S.C. .sctn.371 from International Patent Application No. PCT/JP94/00352, filed Mar. 4, 1994.
FIELD OF THE INVENTION
The present invention relates to the method for preparing Lewis-related compounds, especially Lewis x (Le.sup.x) and Lewis a (Le.sup.a) as well as
Ceramide derivatives, method for preparing the same, and therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives
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TECHNICAL FIELD
The present invention relates to novel ceramide derivatives, a method for preparing the same, and a therapeutic agent for treating atopic dermatitis comprising the ceramide derivatives as active ingredients, and more particularly to novel ceramide derivatives, a method for preparing
Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
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1. FIELD OF THE INVENTION
The invention relates to cationic ceramides, dihydro ceramides, their analogs and their derivatives. The invention also relates to methods of making the compounds and various uses of the compounds, such as the prevention and treatment of diseases associated with cell
Compositions and methods for preventing or treating an inflammatory response
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BACKGROUND OF THE INVENTION
Cystic fibrosis is the most common lethal hereditary disease among Caucasians and it is characterized by a biochemical abnormality in CFTR (cystic fibrosis transmembrane conductance regulator) channel. The most common clinical manifestation in cystic fibrosis is chronic
Compositions and methods for preventing or treating an inflammatory response
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BACKGROUND OF THE INVENTION
Cystic fibrosis is the most common lethal hereditary disease among Caucasians and it is characterized by a biochemical abnormality in CFTR (cystic fibrosis transmembrane conductance regulator) channel. The most common clinical manifestation in cystic fibrosis is chronic
Screening assays for cancer chemopreventative agents
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TECHNICAL AREA OF THE INVENTION
The invention relates to the area of cancer chemopreventative agents. More particularly, the invention relates to the area of screening assays for cancer chemopreventative agents.
BACKGROUND OF THE INVENTION
Because common epithelial cancers have resisted most
Methods for treating cardiac reperfusion injury
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FIELD OF THE INVENTION
The present invention relates to the use of de novo ceramide synthesis pathway inhibitors, particularly myriocin, to treat cardiac reperfusion injury.
BACKGROUND OF THE INVENTION
Although necessary to recover myocardial function, reperfusion of infarcted tissue is a cause of
Methods for treating GI syndrome and graft versus host disease
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 25, 2017, is named 115872-1306_SL.txt and is 21,238 bytes in
Methods for treating GI syndrome and graft versus host disease
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention is in the field of methods for treating and preventing GI Syndrome and Graft Versus Host Disease.
2. Description of the Related Art
Radiation remains one of the most effective treatments for a wide variety of malignant cells;
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