clausenamide/clausena lansium

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[Isolation and structural elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels].

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γ- and δ-Lactams from the Leaves of Clausena lansium.

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Eight new clausenamides, including three γ-lactams (1-3), four δ-lactams (4-7), and an amide (8), and seven known lactams, including compounds 9-11, which were purified from natural sources for the first time, were characterized from the leaves of Clausena lansium. Their structures were elucidated

A New Monoterpenoid and a New Flavonoid Glycoside from the Peels of Clausena lansium.

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One new monoterpenoid, nerol oxide-8-carboxylic acid (1), and one new flavonoid glycoside, claulansoside A (2), together with six known compounds, clausenamide (3), quercetin (4), isorhamnetin (5), dihydromyric (6), 2",3"-dihydroxyanisolactone (7) and

Synthesis and activity in enhancing long-term potentiation (LTP) of clausenamide stereoisomers.

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Clausenamide, isolated from aqueous extract of dry leaves of Clausena lansium, a Chinese folk medicine, was found to have potent activity in enhancing LTP and show nootropic activity in animal tests. In order to discovery more potent stereoisomers and to analyze the relationship of

[Metabolic transformation of (-)-clausenamide in rat liver microsomes].

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The metabolic transformation of (-)-clausenamide, isolated from the leaves of Clausena lansium (Lour.) Skeels, was studied in vitro with phenobarbital-induced rat liver microsomal incubate containing the NADPH-generating system. The constitution of the incubation system was optimized and a

[Anti-lipidperoxidation and cerebral protective effects of clausenamide].

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Clausenamide is a compound isolated from Clausena lansium (lour) with the structure similar to piracetam. Pharmacological experiments showed that clausenamide po 100-200 mg/kg prolonged both the duration of gasping after decapitation and the survival time after sc NaNO2 225 mg/kg, clausenamide at

Mechanism of (-)clausenamide induced calcium transient in primary culture of rat cortical neurons.

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(-)clausenamide is a compound isolated from Clausena lansium (lour) Skeel with nootropic effects. At the present study, we investigated the clausenamide induced Ca2+ signaling in primary cultures of rat cortical neurons by using laser confocal microscopy. The mean amplitude of (-)clausenamide (1

Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action.

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Clausenamide (clau) is one of seven novel compounds isolated from Clausena lansium (Lour) skeels. Clau is unusual in that it contains 4 chiral centers yielding 8 pairs of enantiomers. After identification of the configuration of these enantiomers, the synthesis of 16 enantiomers, including optically

(-)Clausenamide facilitates synaptic transmission at hippocampal Schaffer collateral-CA1 synapses.

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Clausenamide is a chiral compound isolated from leaves of the traditional Chinese herb Clausena lansium (lour) Skeels. It has been shown that (-)clausenamide, but not (+)clausenamide, improved learning and memory in amnesia animal models. However, the precise mechanism of clausenamide's actions

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

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Drug-induced liver injury is the major cause of acute liver failure. However, the underlying mechanisms seem to be multifaceted and remain poorly understood, resulting in few effective therapies. Here, we report a novel mechanism that contributes to acetaminophen-induced hepatotoxicity through the

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