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cyclic amp/horúčka
Odkaz sa uloží do schránky
Strana 1 od 67 výsledky
The effect of an inhibitor of adenylate cyclase on the development of pyrogen, prostaglandin and cyclic AMP fevers in the rabbit.
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An exotoxin of Bacillus thuringiensis known to inhibit adenylate cyclase in vitro has been used to investigate the role of cyclic AMP in the pathogenesis of fever in the rabbit. Intra-hypothalamic microinjections of the exotoxin are non-pyrogenic and significantly attenuate the hyperthermia caused
A norepinephrine-cyclic AMP link in the hypothalamic pathways which mediate fever induced by endotoxin and prostaglandin E2 in the rat.
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The changes in rectal temperature, metabolic rate, cutaneous temperatures and respiratory evaporative heat loss produced by an injection of a bacterial endotoxin piromen (4-40 ng in 1 microliter) into the anterior hypothalamus were assessed in conscious rats in both sexes from a wide range of body
Effect of hyperthermia on epididymal cyclic AMP levels in diabetic non-diabetic and hypophysectomized rats.
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The effect of elevated body temperatures on the concentrations of epididymal cyclic AMP levels in non-diabetic, diabetic and hypophysectomized rats was studied. Cyclic AMP levels were increased during hyperthermia in all animals examined. This increase in epididymal cyclic AMP concentration was not
Biochemical changes in malignant hyperthermia susceptible swine: cyclic AMP, inositol phosphates, alpha 1, beta 1- and beta 2-adrenoceptors in skeletal and cardiac muscle.
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It has been presumed that alteration in the concentrations of second messengers leads to alterations in the function of the ryanodine receptor. Consequently, we have determined the basal content of cyclic AMP and inositol phosphates in skeletal and cardiac muscle of malignant hyperthermia (MH)
Effects of sodium salicylate on the febrile response and increased levels of cyclic AMP in cerebrospinal fluid during endogenous pyrogen-induced fever in rabbits.
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To further evaluate the causality between endogenous pyrogen (EP)-induced fever and cyclic adenosine-3',5'-monophosphate (cyclic AMP) level, the effects of sodium salicylate (SS) on the febrile response and increased levels of cyclic AMP in both cerebrospinal fluid (c.s.f.) and plasma during
Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.
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The effect of heat in combination with DL-alpha-tocopheryl (vitamin E) succinate and adenosine 3', 5'-cyclic monophosphate (cAMP) stimulating agents on mouse neuroblastoma cells ( NBP2 ) in culture on the criterion of growth inhibition (due to cell death and inhibition of cell division) was studied.
Calcium, calcium-ATPase and cyclic AMP changes in Ehrlich ascites cells submitted to hyperthermia.
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Increased radiocalcium influx, decreased Ca-ATPase activity and cAMP concentration were observed in Ehrlich carcinoma cells submitted to hyperthermia temperature (45 degrees C). The significant augmentation of mitochondrial calcium that is simultaneous to an inhibition of the calcium pump appears to
Pyrogen and prostaglandin fever in the rabbit-I: Effects of salicylate and the role of cyclic AMP.
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Proceedings: A role for noradrenaline and cyclic AMP in prostaglandin E1 Fever.
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Does cyclic AMP have a role in the pathogenesis of fever in the rabbit?
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The effect of sodium salicylate on dibutyryl cyclic AMP fever in the conscious rabbit.
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Platelet aggregation induced in mice by whole-body hyperthermia.
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Whole-body hyperthermia ( WBH ) induced by 2450-MHz irradiation resulted in a decrease in platelet number in the circulating blood 3.5 hr after irradiation. Afterward, the treated mice developed thrombocytosis which peaked 3 days after WBH . This phenomenon was suppressed by administration of
Central effect of dibutyryl cyclic AMP on the temperature in the conscious rabbit.
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In the rabbit, intracerebroventricular administration of dibutyryl cyclic AMP (DBC) produces fever which is selectively antagonised by phenoxybenzamine. This indicates the involvement of central alpha-adrenoceptors in DBC-induced fever. The decrease in DBC hyperthermia after 6-hydroxydopamine
The pathogenesis of cianidanol-induced fever.
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Recently, there has been a variety of reports of adverse drug reactions during therapy with the flavonoid Cianidanol (Ci), a cytoprotective radical scavenger, especially involving haemolytic anaemia and drug fever. To elucidate whether the fever was due to a direct, antigen-independent interaction
Evidence against adenosine 3',5'-monophosphate as a mediator of fever in the brain.
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The aim of this study was to test the hypothesis that increased concentrations of adenosine 3',5'-monophosphate (cyclic AMP) in the pyrogen-sensitive preoptic/anterior hypothalamic region (PO/AH) mediate fever. Micro-injection of N6-2'-O-dibutyryl adenosine 3',5'-monophosphate (db cyclic AMP) into
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