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Chronic toxicity of diethyl phthalate in male Wistar rats--a dose-response study.

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Diethyl phthalate (DEP) is widely used in personal care products, plastics and medical devices at various concentrations, but its information is limited on its toxicity associated with exposure at high as well as low doses for a prolonged period. Therefore, a study was undertaken to understand the

Chronic toxicity of diethyl phthalate-A three generation lactational and gestational exposure study on male Wistar rats.

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Diethyl phthalate (DEP) is widely used in the perfume industry as a vehicle for fragrances and in personal care products making human exposure of DEP significant to adults as well as neonatals, as confirmed by levels recorded in blood as well as breast milk samples of human populations in some parts

Combined and individual administration of diethyl phthalate and polychlorinated biphenyls and its toxicity in female Wistar rats.

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Polychlorinated biphenyls (PCBs) are persistent environmental pollutants and known to act as xenoestrogens. PCBs and diethyl phthalate (DEP) are ubiquitous environmental pollutants because both are used as plasticizers and in various other industrial applications. Therefore, a study was undertaken

A two-generation chronic mixture toxicity study of Clophen A60 and diethyl phthalate on histology of adrenal cortex and thyroid of rats.

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This study was undertaken to observe the type of interaction that exists between polychlorinated biphenyls (Clophen A60) and diethyl phthalate (DEP) on the adrenal and thyroid glands of male and female Wistar rats. Animals were divided into four groups of six animals each, group I male and female

Toxicity study of maternal transfer of polychlorinated biphenyls and diethyl phthalate to 21-day-old male and female weanling pups of Wistar rats.

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Polychlorinated biphenyls (PCBs) are environmental pollutants known to act as xenoestrogens. PCBs and diethylphthalate (DEP) are ubiquitous environmental pollutants because both are used as plasticizers and in various other industrial applications. Therefore, a study was undertaken to evaluate the

The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo.

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Phthalate esters are widely used in the manufacture of plastics and have been shown to cause testicular toxicity, purportedly, by targeting the Sertoli cell alone. Recent evidence, however, indicates that a paracrine control exists between Sertoli and Leydig cells and the breakdown of one component

Microencapsulation of pancreatic islets in a water insoluble polyacrylate.

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Rat pancreatic islets were encapsulated in a water insoluble polyacrylate (Eudragit RL), a model polymer, by coaxial extrusion and interfacial precipitation. Despite exposure to organic solvents and nonsolvents (diethyl phthalate, corn oil, and mineral oil) and to shear, the islets survived

Microencapsulation of mammalian cells in a water-insoluble polyacrylate by coextrustion and interfacial precipitation.

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A process for the microencapsulation of mammalian cells in a commercially available water-insoluble polyacrylate (EUDRAGIT RL) is described, and the effects of process parameters are outlined The polymer dissolved in diethyl phthalate was pumped along the annulus formed from two concentric needles,

Fate and transport modeling of phthalate esters from biosolid amended soil under corn cultivation.

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Phthalate esters (PAEs) are prevalent in the environment due to the broad range of industrial, agriculture and domestic applications. The ubiquitous use of PAEs has resulted in their potential to reach groundwater sources through application of agri-chemicals and municipal biosolids. A study was

Microencapsulation of human fibroblasts in a water-insoluble polyacrylate.

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Viable human diploid fibroblasts have been micro-encapsulated in EUDRAGIT RL, a commercially available water-insoluble polyacrylate, by an interfacial precipitation technique. Cells in medium and polymer solution (in diethyl phthalate) were coextruded and formed into droplets by a coaxial air

Final report on the safety assessment of phytantriol.

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Phytantriol is an alcohol used in around 100 cosmetic products at concentrations ranging from 0.0002% to 1.0%, although uses at concentrations up to 3% are under development. Phytanriol is supplied at 95.2% and 96.0% purity. Impurities include water, sulphated ash, heavy metals, and a diastereomer

The toxic effect of phthalate esters on immune responses of giant freshwater prawn (Macrobrachium rosenbergii) via oral treatment.

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A previous in vitro study has indicated that four phthalate esters (PAEs) could damage hemocytes and decreases the cellular immunity of prawns [Sung, H.H., Kao, W.Y., Su, Y.J., 2003. Effects and toxicity of phthalate esters to hemocytes of giant freshwater prawn, Macrobranchium rosenbergii. Aquat.

Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells.

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In utero exposure to certain phthalate esters results in testicular toxicity, characterized at the tissue level by induction of multinucleated germ cells (MNGs) in rat, mouse, and human fetal testis. Phthalate exposures also result in a decrease in testicular testosterone in rats. The

Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis.

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Male reproductive tract abnormalities associated with testicular dysgenesis in humans also occur in male rats exposed gestationally to some phthalate esters. We examined global gene expression in the fetal testis of the rat following in utero exposure to a panel of phthalate esters. Pregnant

Exposure to an environmentally relevant phthalate mixture during prostate development induces microRNA upregulation and transcriptome modulation in rats.

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Environmental exposure to phthalates during intrauterine development might increase susceptibility to neoplasms in reproductive organs such as the prostate. Although studies have suggested an increase in prostatic lesions in adult animals submitted to perinatal exposure to phthalates, the molecular

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