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diphenylhydantoin/seizures
Odkaz sa uloží do schránky
Strana 1 od 345 výsledky
Effects of diazepam and diphenylhydantoin on elicited and spontaneous seizures in kindled rats: a double dissociation.
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Diazepam (1 mg/kg) was more effective than diphenylhydantoin (100 mg/kg) in suppressing motor seizures elicited in kindled rats by amygdaloid stimulation; however, the effect of these drugs on the incidence of spontaneous motor seizures in rats kindled by amygdaloid stimulation was just the
Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats.
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Procaine HCl and diphenylhydantoin (DPH) increased the duration and propagation of epileptiform afterdischarges (ADs) produced by electrical stimulation of the amygdala in rats. Procaine and DPH also increased the rate of seizure development (kindling) produced by repeated stimulation of the
Chromosome fragile sites in mentally retarded males: increased incidence with seizures and diphenylhydantoin therapy.
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Chromosome fragile site or lesion data were examined in 154 institutionalized mentally retarded males with or without seizures or treated with anti-seizure medication. Blood lymphocytes were cultured using three different cell culture conditions and the incidence of specific chromosome fragile sites
Diphenylhydantoin induced granulocytopenia following a seizure prophylaxis after a depressed skull fracture.
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The article deals with a rare case of granulocytopenia following a seizure prophylaxis after a severe head injury. Although fatal complications like the one described occur extremely seldom, we want to emphasize the necessity of regular controls during the critical time period between the 10th and
Effects of withdrawal from long-term diphenylhydantoin treatment on audiogenic and maximal electroshock-induced seizures in rats.
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Rats withdrawal from long-term diphenylhydantoin treatment (DPH) were tested for their sensibility to convulsant stimuli. Animals were more sensitive to convulsions elicited by maximal electroshock and sound, respectively, at 48 and 72 h after drug removal. These results suggest that long-term DPH
Plasma levels of diphenylhydantoin and the control of adult epileptic seizures: a Chilean experience.
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In a prospective study of 117 adult ambulatory patients, 110 of whom were epileptics treated only with oral diphenylhydantoin (DPH), plasma levels of this drug were determined by gas-liquid chromatography. The average follow-up time was 6 months (range, 3 to 13 months); satisfactory control of
Studies of Qingyangshen (II): modulatory effect of co-treatment with qingyangshen and diphenylhydantoin sodium on rat hippocampal c-fos expression during seizures.
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We have reported that, after KA treatment in rats, there was first a significant increase in hippocampal c-fos expression during acute seizures and then a long-term inhibition in hippocampal c-fos expression during chronic seizures. In this experiment, we examined the modulatory effect of
Effect of non-steroidal anti-inflammatory drugs on the anticonvulsive activity of valproate and diphenylhydantoin against maximal electroshock-induced seizures in mice.
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Prostaglandins and their inhibitors may affect convulsive phenomena. Thus, the aim of this study was to examine possible interactions between non-steroidal anti-inflammatory drugs and two conventional antiepileptic drugs in terms of their anticonvulsive activity and side-effects. Also, the plasma
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
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The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures. Diphenylhydantoin remained without influence upon the chemically induced convulsions but potentiated the
Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice.
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delta9-Tetrahydrocannabinol (THC) was compared with diphenylhydantoin (DPH), phenobarbital (PB) and chlordiazepoxide (CDP) using two electroshock procedures to determine anticonvulsant activity in mice, i.e., electroshock seizure threshold (EST) and the reduced EST caused by hyponatremia (injection
Differential effects of baclofen, gamma-hydroxybutyric acid and muscimol on the protective action of phenobarbital and diphenylhydantoin against maximal electroshock-induced seizures in mice.
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This study was designed to compare the effects of baclofen (a GABAB agonist), muscimol (a GABAA agonist) and gamma-hydroxybutyric acid on the protective action of phenobarbital (PB) and diphenylhydantoin (DPH) against electroshock-induced convulsions. All drugs were given intraperitoneally, muscimol
Phenobarbital and diphenylhydantoin levels in neonates with seizures.
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Little information is available regarding appropriate plasma levels of anticonvulsant drugs in neonates. We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures. Following intravenous
Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin.
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Generalized EEG seizures were induced in acute, conscious New Zealand albino rabbits with intravenous pentylenetetrazol (PTZ) (10 or 15 mg/kg) or electrical stimulation of the frontal cerebral cortex (ELEC) (50 Hz, 1 msec pulse duration, 2 sec train duration, 4.0-7.6 V). Three anticonvulsant
Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.
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This study, a 4-month follow-up period of a 12-month treatment study by the present authors, was concerned with the permanent effects of treatment with diphenylhydantoin and phenobarbital in the alumina-gel monkey model. Whereas the 8 drug animals during withdrawal increased their seizure frequency,
Prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. I. Twelve months of treatment: seizure, EEG, blood, and behavioral data.
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Utilizing an alumina-gel epileptic monkey model, with instrumentation for continuous monitoring of all overt, spontaneous motor seizures, the efficacy of pharmacologic prophylactic treatment of posttraumatic epilepsy was explored. The alumina-gel model provides a relatively standardized brain trauma
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