Laboratory investigations :
complete blood count
renal and liver function tests
serum ferritin
lipid profile
Interleukin -6
HsC-RP
Adiponectin level
Imaging :
Abdominal ultrasound
Echocardiography
Carotid intima media thickness

Thalassemia

serum samples used for doing the test by ELISA

Interleukin-6

HsC-RP

Adiponectin level

Carotid intima media thickness

Assiut University Hospital

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Adiponectin, Interleukin-6 (IL-6) and High Sensitive C-reactive Protein (hsC-RP) in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Asmaa Nady Hussein

Principal investigator

Assiut University

A pilot study will be done on 20 patients with abnormal glucose tolerance which will include:
A-Continuous glucose monitoring system (CGMS) : A glucometer will be given to each patient and will be asked to measure blood glucose before meals and snacks and record the valus in the CGMS for better calibration (Khammar A et al., 2009).
B-Therapeutic intervention:
Thalassemia patients who proved to have diabetes according to the ADA criteria will be put on sc insulin

A pilot study will be done on 20 patients with abnormal glucose tolerance which will include:
A-Continuous glucose monitoring system (CGMS) : A glucometer will be given to each patient and will be asked to measure blood glucose before meals and snacks and record the valus in the CGMS for better calibration (Khammar A et
B-Therapeutic intervention:
Thalassemia patients who proved to have diabetes according to the ADA criteria will be put on insulin pump

Diabetes

Prediabetes

B-Thalassemia

A-Continuous glucose monitoring system (CGMS) : A glucometer will be given to each patient and will be asked to measure blood glucose before meals and snacks and record the valus in the CGMS for better calibration (Khammar A et al., 2009).
B-Therapeutic intervention:
Thalassemia patients who proved to have diabetes according to the ADA criteria will be subjected to
• Insulin pump will be tried in each diabetic thalassemic patient versus conventional insulin therapy(Bruttomesso D et al., 2009).

insulin pump/CGMS

The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients

Evaluation of Continuous Blood Glucose Monitoring Method for Detection of Alterations in Glucose Homeostasis in Beta Thalassemia Patients

to find out the number of patients with thalassemia major having impaired glucose tolerance

to find out the number of patients with thalassemia major having diabetes mellitus

to compare the use of conventional insulin therapy to insulin pump in diabetic thalassemic patients

hemoglobinopathies/obezita

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients

Maternal Obesity and Small for Gestational Age Infants

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