subjects will be provided with Ashwagandha capsules 500 mg twice daily, after meals with plain water for 1 month

subjects will be provided with placebo capsules.

Chronic Periodontitis

ashwagandha capsules given to the subjects twice daily after meals for 1 month

Ashwagandha

placebo capsules given twice daily after meals for 1 month

Placebo

Tatyasaheb Kore Dental College

Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis

Effect of Ashwagandha (Withania Somnifera) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant and Serum c Reactive Protein Levels in Chronic Generalized Periodontitis- a Randomized Double Blind Clinico-biochemical Trial

c reactive protein levels by nephelometry

super oxide dismutase levels by biochemical kazaridas method

clinically assessed its a scale ranging from 0 to 3,in which 0 being the least and 3 being the highest

Dr.Nibha Suneel Kulkarni

Principal Investigator

Intervention consists of daily administration of 2g probiotic Lactobacillus casei Zhang, administered daily at a fixed dosage of 9 log CFU/sachet/day and continue for 12 months.

Intervention consists of daily administration of 2g placebo (no probiotic bacteria), administered daily and continue for 12 months.

Healthy Volunteers

This project aims to study the benefits of probiotics namely Lactobacillus casei Zhang in prevention of upper respiratory and gastrointestinal illnesses, among adults in Malaysia aged from 18-81 years.

Lactobacillus casei Zhang

School of Industrial Technology, Universiti Sains Malaysia

Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults

Effects of Lactobacillus Casei in the Prevention of Upper Respiratory and Diarrheal Diseases Among Adults

IgA as an indicator for immunology, in assessing severity of upper respiratory illnesses between number of adult participants taking LCZ vs. placebo

Bristol stool scale (from a scale of 1-7; scale of 1 representing hard lump, and 7 representing liquid with no solid pieces) as an indicator for assessing severity of gastrointestinal-related diarrheal illnesses between number of adult participants taking LCZ vs. placebo

Deoxyribonucleic acid (DNA) sequencing of fecal samples to compare DNA sequences of the different microbiota between adult participants taking LCZ vs. placebo

horse/antibakteriálne

Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis

Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults

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