horse/antidepresívum

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Elimination of doxepin isomers from the horse following intravenous application.

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The tricyclic antidepressant doxepin, representing a 5:1 mixture of trans- and cis-isomers, owns tranquilizing properties. This compound has been associated with illicit medication of racing horses, and therefore should be considered in doping control. Because analysis of doxepin in equine body

Human xylazine overdose: a comparative review with clonidine, phenothiazines, and tricyclic antidepressants.

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We report a case of horse tranquilizer (xylazine) overdose from oral ingestion in man, detail a gas-liquid chromatography/mass spectrometer method for xylazine assay in the blood and urine, and suggest the management of acute poisoning. We present a comparative review of some toxicological

Enhanced antidepressant-like effects of the macromolecule trefoil factor 3 by loading into negatively charged liposomes.

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Immunocytes, mainly neutrophils and monocytes, exhibit an intrinsic homing property, enabling them to migrate to sites of injury and inflammation. They can thus act as Trojan horses carrying concealed drug cargoes while migrating across impermeable barriers to sites of disease, especially the

The isomeric metabolites of doxepin in equine serum and urine.

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Due to its tranquilizing properties, the tricyclic antidepressant doxepin may be misused as a doping agent in competition horses. Therefore, efficient analytical procedures are required to detect this drug in samples submitted for doping control. To screen for parent doxepin in equine blood and

Clinical similarities and close genetic relationship of human and animal Borna disease virus.

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Borna disease virus (BDV) is the prototype genus of a new family, Bornaviridae, within the order Mononegavirales. BDV naturally infects animals and man. The symptomatology in animals ranges from subclinical infection to rare cases of encephalitis. Asymptomatic infection seemed more frequent than

Interaction of lectins with human platelet serotonin transporter.

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Lectin affinity chromatography was used to demonstrate the glycoprotein nature of the serotonin (5-HT) transporter. The human platelet transporter protein was solubilized with 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS), labelled with [3H]cyanoimipramine and chromatographed on

Canine and Equine Therapy for Mental Health: A Review of Clinical Effectiveness

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Animals have been used for medicinal and therapeutic purposes throughout much of the course of human history.¹^,² Formal research into the use of animals for therapeutic purposes being in the 1960s, where work investigating the use of pet psychotherapy for treatment

Effect of ascorbate on Na(+)-independent and Na(+)-dependent uptake of [3H]norepinephrine by rat primary astrocyte cultures from neonatal rat cerebral cortex.

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We have previously reported that primary astrocyte cultures prepared from neonatal rat brains show Na(+)-dependent, tricyclic antidepressant-sensitive, high-affinity uptake of [3H]norepinephrine ([3H]NE). Other workers, however, using primary astrocyte cultures from neonatal mice, have failed to

What is the place of psychological treatments in mood disorders?

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While psychotherapy has many applications for mood disorders, this paper focuses on those psychotherapies (cognitive behaviour therapy or CBT, and interpersonal psychotherapy or IPT) that have been manualized, extensively evaluated, and positioned as definitive therapies for unipolar depressive

Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages.

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HIV type 1 (HIV-1) infects CD4(+) T lymphocytes and tissue macrophages. Infected macrophages differ from T cells in terms of decreased to absent cytopathicity and for active accumulation of new progeny HIV-1 virions in virus-containing compartments (VCC). For these reasons, infected macrophages are

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Herbal & Natural Medicine

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