Autologous hematopoietic stem cell transplantation will be performed after conditioning regimen of cyclophosphamide 200 mg/kg/intravenously(IV), rATG(thymoglobulin) 5.5 mg/kg/IV and rituximab 1000mg/IV.

Hematopoietic Stem Cell Transplantation for CIDP

Sex: Female, Male

Region of Enrollment

Survival of participants who survived the treatment and up to 5 years post treatment.

Autologous hematopoietic stem cell transplantation will be performed after conditioning regimen of cyclophosphamide 200 mg/kg/intravenously(IV), rATG(thymoglobulin) 5.5 mg/kg/IV and rituximab 1000mg/IV

Number of Participants With Survival

Post transplant immune medication-free remission with stable or improving neurological exam

Disease Improvement - Medication Free Remission

Disease Improvement - Requires No Assistance to Ambulate

Disease Improvement - Ambulatory Assistance

Change in the Medical Research Council (MRC) Scale: range is 0 (quadriplegic) - 60 (normal).

Change in Disability and Strength Functional Scales

Hematopoietic Stem Cell Transplantation

Overall Study

Kathleen Quigley

Chronic Inflammatory Demyelinating Polyneuropathy

Autologous hematopoietic stem cell transplantation

hematopoietic stem cell transplantation

Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Northwestern University, Feinberg School of Medicine

Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy

Non-myeloablative Autologous Hematopoietic Stem Cell Transplantation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Trial

Richard Burt, MD

Northwestern University

Premedication with 3 mg melatonin (Meloset) tablet orally 1-2 hour prior to anesthesia

Premedication with 3 mg melatonin and 0.5 mg alprazolam (Stresnil) tablet orally 1-2 hrs prior to anesthesia

Premedication with 0.5 mg alprazolam (Alprax) tablet orally 1-2 hr prior to anesthesia

Premedication with a similar looking placebo tablet orally 1-2 hr prior to anesthesia

premedication 1-2 hour prior to anesthesia

Melatonin

Melatonin and Alprazolam

Alprazolam

Placebo

Total

VAS (Visual Analogue Score) Anxiety Scale is 10 cm long and has the patient's side (front) and the clinician's side (back). The extremes of the front are colored as white and black; with a gradual darkening of color from white to black in between. The back is marked in centimeter from 0 to 10 and 0 correlates with white color (no anxiety at all) and 10 correlates to black color (anxiety as bad as ever can be). The patient is asked to point at the color on the scale according to his anxiety level. As anxiety is worsened, the score is more. The maximum value of assessment is 10 and minimum is 0.

Vas baseline (cm)

Anaesthesia time

VAS (Visual Analogue Score) Anxiety Scale is a 10 cm long scale with two sides, the patient side (front) and the clinicians side (back). The extremes of the front are colored as white and black with a gradual darkening of color from white to black. The back is marked in centimeter from 0 to 10 and 0 correlates with white color (no anxiety at all) and 10 correlates to black color (anxiety as bad as ever can be) on the front. As anxiety is worsened, the color is darker and score is more. The maximum score is 10 and minimum 0. The patient is asked to point on the scale according to his anxiety level. The anxiety score is the correlating number on the clinicians side. The more the reduction in anxiety from baseline, the better the outcome.

Change in VAS Anxiety Score Relative to Baseline After Premedication

Sedation level was assessed with a 5 point scale (0=alert, 1=arouses to voice, 2=arouses with gentle tactile stimulation, 3=arouses with vigorous tactile stimulation, 4=lack of responsiveness). Minimum score is 0 and Maximum is 4. The lesser the score, the better the outcome.

Sedation Score at One Hour After Premedication

Orientation was assessed with a 3 point scale (0=none, 1=orientation in either time or place, 2=orientation in both). Minimum score is 0 and maximum is 2. The lesser the score, the lesser the effect on patients cognition and the better the outcome.

Orientation Score

Number of patients who recalled or recognized the picture number five shown one hour after premedication. The more the number of patients with intact memory, the better the outcome.

Number of Patients With Intact Memory

Dose of propofol needed for loss of response to verbal command was noted at the time of induction of general anesthesia. The lesser the propofol needed for the loss of response to verbal command, the better the outcome.

Amount of Propofol Consumption

Change in VAS Anxiety Score Relative to Baseline at 30 Minutes After Premedication

Change in VAS Anxiety Score Relative to Baseline at One Hour After Premedication

Patients were asked whether they recalled the event of being transferred to the operating room before anaesthesia. The lesser the number of patients with amnesia, the better the outcome.

Number of Patients With Loss of Memory for Being Transferred to Operating Room.

Oral premedication with 3 mg melatonin tablet (Meloset) 1-2 hour prior to anesthesia

Oral premedication with a 3 mg melatonin and 0.5 mg alprazolam combination tablet (Stressnil) 1-2 hrs prior to anesthesia

Oral premedication with 0.5 mg alprazolam (Alprax) 1-2 hr prior to anesthesia

Oral premedication with a similar looking placebo tablet 1-2 hr prior to anesthesia

Dr Krishna Pokharel

Anxiety

3 mg melatonin tablet 1-2 hour prior surgery

meloset (melatonin)

3 mg melatonin and 0.5 mg alprazolam 1-2 hr before anesthesia

stresnil ( melatonin and alprazolam)

(alprax) alprazolam

placebo

B. P. Koirala Institute of Health Sciences

Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone

Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone: a Randomized, Double Blind Placebo Controlled Study

Krishna Pokharel

Associate Professor

B.P. Koirala Institute of Health Sciences

We randomly allocated patients to treatment with IVIG or placebo. Children received either saline or intravenous immunoglobulin (IVIG) [ImmunoRel™ (batch 20081217)] at a dose of 400mg/kg/day for 5 days or an equivalent volume of 0.9% normal saline given intravenous at the rate of 0.01 to 0.02 ml/kg body weight/minute. All investigators, care providers and participants were blinded of the study drug. A second sealed envelope was kept with the patient's notes in case a physician urgently needed to know which drug a patient had received.

Japanese Encephalitis

IVIG group received 400mg/kg/day intravenous at the rate of 0.01 to 0.02 ml/kg body weight/minute for 5 days or appearance of side effect or adverse events.
Placebo group received 0.9% saline intravenous at similar rate.

Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]

Kanti Children's Hospital

BP Koirala Institute of Health Sciences

Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis

A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal

Patients will be monitored for side effects such as infusion site reaction, diarrhea, rise in blood pressure (in mm Hg) and change in urinary output (in ml/Kg/hour) every 12 hours from first day of commencing treatment until until death or discharge. Patient on average are administered the study drug on the first day of admission. The study drug is administered daily for 5 days. Patients are discharged on an average on eighth day (192 hours) of hospital admission.

At the time of discharge(expected average of eighth day of admission) or death: Time to death, to recover from coma, to sit independently, to stand independently, to walk at least 5m independently, and to leave hospital.
At 6 months after discharge: history of further seizures, behavioral changes, evidence of recovery of neurological sequelae such as assessment of ability to sit independently, to stand independently, to walk at least 5 meters independently.

Pre-treatment was immediately prior to the first dose of study drug on the first day, mid-treatment was immediately prior to the 4th dose and post-treatment was 1hour after administering the fifth dose of the study drug.

horse/bolesť hlavy

Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy

Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone

Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis

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