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6 výsledky
Active ingredients from natural botanicals in the treatment of obesity.
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Obesity is considered as a chronic disease that can induce a series of comorbidities and complications. Chinese medicine has long clinical experiences in the treatment of obesity. This review summarizes the natural products from traditional Chinese medicine (TCM) that are reported to have
Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats.
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We investigated the effect of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl), a marker compound isolated from the cortex of Magnolia officinalis, in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with magnolol (100 mg/kg body weight) once a day for 13 weeks. In
Magnolol inhibits venous remodeling in mice.
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Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In fact, chronically elevated venous pressure was
Magnolol promotes thermogenesis and attenuates oxidative stress in 3T3-L1 adipocytes.
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OBJECTIVE
The aim of this study was to explore the browning and antioxidative effects of magnolol in 3T3-L1 adipocytes, as recruitment of beige-like adipocytes (browning) by natural compounds is being considered as a promising strategy to fight against obesity.
METHODS
Magnolol-induced browning
Magnolol induces adipogenic differentiation in human skin.
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The skin adipose tissue participates in energy storage, thermogenesis, endocrine secretion, fibrosis and scarring, and innate immune defense.1 Furthermore, the facial subcutaneous fat is important for skin aging such as elasticity and wrinkle formation.2,3 The subcutaneous
A novel triazine ring compound (MD568) exerts in vivo and in vitro effects on lipid metabolism.
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In this study, we investigated the toxicity and biological activity of a novel triazine ring compound named magnolol derivative 568 (MD568). The LD50 of MD568 was determined in Sprague-Dawley (SD) rats by intraperitoneal injection. Treatment of high fat diet-induced obese rats with MD568
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