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Urinary N-acetyl-beta-D-glucosaminidase as a marker of renal injury in adjuvant arthritis.

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In the present study we have determined if renal damage occurs with adjuvant arthritis (AA). As a sensitive indicator of renal injury in tubular cells, urinary N-acetyl-beta-D-glucosaminidase (NAG) was measured at predetermined times after arthritis induction. Urinary protein, sodium and potassium

On the histochemistry of N-acetyl-beta-D-glucosaminidase in rat central nervous system.

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The optimal conditions for histochemical demonstration of NAG activity in the cerebrum, diencephalon, midbrain, cerebellum, medulla oblangata, and spinal cord were studied in a series of 37 Wistar rats of either sex. The following more important results were obtained: Each CNS zone required a

Investigation of the renal injury caused by liver ischemia-reperfusion in rats.

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To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide

[Renal impairment in patients with methylmalonic aciduria: a review of five cases].

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OBJECTIVE The renal impairment in children with methylmalonic aciduria has seldom been reported. To improve knowledge in this aspect, clinical data of five cases with methylmalonic aciduria with renal involvement were analyzed and the results are reported in this paper, which may be of some help in

Tubulointerstitial nephritis and uveitis syndrome associated with hyperthyroidism.

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We report a 17-year-old male patient with tubulointerstitial nephritis and uveitis (TINU) associated with hyperthyroidism. He presented with a 2-month history of fatigue, loss of appetite, low-grade fever, and a 12-kg weight loss when he was admitted to our hospital. He had iritis, which was

[Study on correlation between TCM syndrome and urinary protein in patients with early chronic kidney diseases].

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OBJECTIVE To analyze the characteristics of TCM syndrome distribution and its correlation with urinary protein in patients with early chronic kidney diseases (CKD), for the sake of providing a basis for clarifying the rules of TCM syndrome differentiation in CKD. METHODS Adopting traditional

Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism.

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OBJECTIVE To investigate the anti-inflammatory effects and mechanism of recombinant human superoxide dismutase (rhSOD). METHODS Inflammation models such as croton oil-induced ear swelling and carrageenan-induced hind paw edema in mice and rats were prepared. The nitric oxide synthase (NOS ) activity

[High sensitive photometric assay of pancreatic lipase and clinical investigation of urinary lipase in patients with various histopathological types of primary glomerulonephritis].

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We measured the activity of urinary lipase by high sensitive photometric method using 1,2-dirinoleoilglycerol as a substrate. Also, we investigated the clinical significance of the activity of urinary lipase in patients with chronic glomerulonephritis (GN) with special reference to the relation

Infusion of radiocontrast agents induces exaggerated release of urinary endothelin in patients with impaired renal function.

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BACKGROUND The aim of the study was to examine the role of endothelin in radiocontrast-induced nephropathy (RCN) in patients with chronic renal failure. METHODS We measured plasma endothelin-1 (ET) and the urinary excretion of endothelin-like immunoreactivity before and after infusion of radio

Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure.

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Metallothionein (MT) is a low-molecular-weight, cysteine-rich, metal-binding protein. Induction of MT has been proposed to be an important adaptive mechanism in decreasing Cd toxicity. MT has been shown to protect against CdCl2-induced lethality and hepatotoxicity; however, MT does not protect

Evidence of Bioactive Compounds from Vernonia polyanthes Leaves with Topical Anti-Inflammatory Potential.

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Vernonia polyanthes Less. (Asteraceae), popularly known as "assa-peixe", is a plant species used in Brazilian traditional medicine for the treatment of cutaneous damage, cicatrization, inflammation, and rheumatism. Based on these ethnopharmacological findings, the current study evaluated the topical

Short-term pulmonary response to inhaled JP-8 jet fuel aerosol in mice.

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B6.A.D. (Ahr(d)/Nat(s)) mice were utilized to investigate the short-term pulmonary response to JP-8 jet fuel (JP-8) aerosol inhalation. Mice were nose-only exposed to atmospheres of 0 to 118 mg/m3 for 1 h/d over a period of 7 days to further test the hypothesis that JP-8 concentrations below the

[Correlation between urinary biomarkers and pathological lesions in drug-induced tubulointerstitial nephritis].

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OBJECTIVE To find some urinary biomarkers for differential diagnosis in drug-induced tubulointerstitial nephritis (DTIN) by accessing the relationship between their changes and the pathological processes of DTIN. METHODS Forty patients biopsy-proven DTIN and 24 healthy controls were enrolled in this

Investigation of anti-inflammatory and anti-proliferative activities promoted by photoactivated cationic porphyrin.

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BACKGROUND Photodynamic therapy (PDT) is a technique that uses light and a photosensitizer, converting local molecular oxygen into singlet oxygen, which eliminates a target unhealthy tissue. It has been increasingly used for the treatment of several diseases including skin disorders. Psoriasis is a

[Effects of extracorporeal shock waves on renal morphology, renal function and blood pressure in rats--follow-up for one year].

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Effects of extracorporeal shock waves on renal tissue, renal function, and blood pressure were studied by applying 500 shock waves to both kidneys in 72 female Wistar rats. Six groups, 12 rats in each, were sacrificed on days, 1, 7 and at months 1, 3, 6 and 12 after the procedure, when serum levels

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