neuralgia/hnačka

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Acupuncture and migraine prophylaxis, probiotics and C. Difficile-associated diarrhea, preventive group counseling and postpartum depression, black cohosh and menopausal symptoms, deep needling electroacupuncture and trigeminal neuralgia.

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Fulranumab for treatment of diabetic peripheral neuropathic pain: A randomized controlled trial.

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OBJECTIVE To assess efficacy and safety of fulranumab, a fully human monoclonal antibody against nerve growth factor, in patients with diabetic peripheral neuropathic pain (DPNP). METHODS In this phase II, double-blind, placebo-controlled trial, patients with moderate to severe DPNP were randomized

Long-term Safety and Efficacy of Mirogabalin in Asian Patients with Diabetic Peripheral Neuropathic Pain.

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INTRODUCTION

Diabetic peripheral neuropathic pain (DPNP) affects the functionality, mood, and sleep patterns of patients with diabetes. Mirogabalin, an α₂ δ ligand with a slower dissociation for α₂ δ-1 vs α₂ δ-2 subunits, demonstrated efficacy and

Tolerability and safety of gastroretentive once-daily gabapentin tablets for the treatment of postherpetic neuralgia.

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OBJECTIVE An immediate-release formulation of gabapentin is approved for treatment of postherpetic neuralgia (PHN). This formulation, however, requires multiple daily dosing, usually three times per day, and is associated with a high incidence of somnolence and dizziness. We assessed the

Construct validity of an instrument to measure neuropathic pain in women with bladder pain syndrome.

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OBJECTIVE To determine the construct validity of an instrument to measure neuropathic pain in women with bladder pain syndrome (BPS). Our hypothesis is that neuropathic, bladder, and bowel pain represent different constructs in women with BPS. METHODS Secondary planned analysis of a prospective

Association of neuropathic pain with bladder, bowel and catastrophizing symptoms in women with bladder pain syndrome.

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OBJECTIVE In this study we determined if there is an association of neuropathic pain with urinary, bowel and catastrophizing symptoms in women with bladder pain syndrome. METHODS Female patients with a diagnosis of bladder pain syndrome completed validated questionnaires to assess neuropathic pain,

Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.

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Chronic morphine exposure induces physical dependence and tolerance. Previous studies have shown that there is a decrease in met-enkephalin levels in states of morphine physical dependence, and that increasing enkephalin during opiate physical withdrawal ameliorates the severity of the morphine

Efficacy and safety of gabapentin for treatment of postherpetic neuralgia: a meta-analysis of randomized controlled trials.

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BACKGROUND Postherpetic neuralgia (PHN) is a common type of neuropathic pain occurring after resolution of herpes zoster rash. Although gabapentin is a widely used treatment, some disagreements exist about its efficacy and safety. Meta-analysis was performed to better evaluate the efficacy and

Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: results of an open-label, phase 3b study.

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OBJECTIVE This open-label, phase 3b study evaluated the effectiveness and tolerability of tapentadol prolonged release and tapentadol immediate release (for acute pain episodes) for severe, chronic low back pain with or without a neuropathic pain component that was inadequately managed in patients

Mirogabalin besylate in the treatment of neuropathic pain.

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Neuropathic pain (NeP) is a global cause of suffering and debilitation leading to significant morbidity and reduced quality of life. New treatments are needed to address the growing prevalence of NeP and its impact on sleep, mood and functionality. Mirogabalin besylate (mirogabalin, Tarlige) is a

Duloxetine in the management of diabetic peripheral neuropathic pain.

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Diabetic neuropathy affects up to 70% of diabetics, and diabetic peripheral neuropathic pain (DPNP) is the most common and debilitating of the diabetic neuropathies. DPNP significantly reduces quality of life and increases management costs in affected patients. Despite the impact of DPNP, management

Ameliorative potential of Alstonia scholaris (Linn.) R. Br. against chronic constriction injury-induced neuropathic pain in rats.

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BACKGROUND Alstonia scholaris commonly known as 'Saptaparni' is an Indian traditional medicinal plant used in Ayurveda. It is commonly used to treat various disorders like asthma, bronchitis, diarrhea, dysentery and malaria. In folklore medicine the milky juice of the plant is applied on wounds and

Topical loperamide for the treatment of localized neuropathic pain: a case report and literature review.

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Peripheral nerve damage can result in neuronal hyperexcitability, resulting in neuropathic pain. Localized neuropathic pain is confined to a specific area not larger than a letter-size piece of paper. Topical analgesics are increasingly popular for the treatment of localized neuropathic pain because

Effectiveness of prostaglandin E1 for the treatment of patients with neuropathic pain following herpes zoster.

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OBJECTIVE Postherpetic neuralgia (PHN) is one of the most painful neuropathic conditions, the mechanism of which remains unclear. There is no universally accepted treatment. The pain in PHN is often relieved by bathing, heating, or sympathetic blockade, suggesting a circulation-dependent property of

Phase IA Clinical Trial Evaluating the Tolerability, Pharmacokinetics, and Analgesic Efficacy of an Intrathecally Administered Neurotensin A Analogue in Central Neuropathic Pain Following Spinal Cord Injury.

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We evaluated CGX-1160 in a Phase Ia clinical trial to determine the safety of escalating doses in patients with central neuropathic pain following spinal cord injury (SCI). Our secondary objective was to detect a trend toward analgesic efficacy. Four subjects received 3 consecutive escalating doses

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