after 4 weeks of lifestyle advice and changes, all subjects will receive for 8 weeks the administration of CARDIOVIS COLESTEROLO 3 mg, a nutraceutical compound containing containing red rice fermented with Monascus purpureus titrated with 3% monacolin K, hydrol mixture of olive fruit titrated with vitamin E, Coenzyme Q10 and polymethoxyflavones

Hypercholesterolemia

8-week administration of nutraceutical compound

nutraceutical

University Hospital of Ferrara

Nutraceutical in Cardiovascular Primary Prevention

Nutraceutical Compound to Optimize Cholesterol, Endothelial and Inflammatory Parameters in Subjects With Hypercholesterolemia and Low to Moderate Cardiovascular Risk: the NIRVANA Study

rate of apoptosis in human umbilical vein endothelial cells treated with subject's serum

NO generation in human umbilical vein endothelial cells treated with subject's serum

Gianluca Campo

Associate Professor, Interventional Cardiologist

Subjects that meet the inclusion/exclusion criteria and have provided informed consent will undergo a 4-week period of lifestyle advice and changes. If, after the 4 weeks, LDL values are confirmed above the established cutoffs, the subjects receive CARDIOVIS COLESTEROLO 3 mg for 8 weeks. After the 8-week treatment period, all biological paprameters will be reassessed. Finally, a last blood samples to assess a potential rebound effect after nutraceutical suspension is collected 4 weeks after the treatment stop.

oryza eichingeri/protizápalový

Nutraceutical in Cardiovascular Primary Prevention

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