periodontitis/protease

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Alarm Anti-protease Trappin-2 Negatively Correlates With Proinflammatory Cytokines in Patients With Periodontitis.

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BACKGROUND Trappin-2 is one of the potent biologically active serine protease inhibitor with anti-inflammatory properties that has also been characterized as an "alarm anti-protease". Despite the importance of Trappin-2 in several chronic infections has been demonstrated, its potential involvement

[Protease activity of microflora in the oral cavity of patients with periodontitis].

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Microbial spectrum and non-specific as well as specific IgA1 protease activity of isolated microorganisms were investigated in gingival liquid of patients with periodontitis. Microorganisms from the gingival liqud of these patients belonged to conditional-pathogenic obligate and facultatively

Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitis.

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Porphyromonas gingivalis is associated with the development of periodontitis. Here we describe the development of a highly specific protease-based diagnostic method for the detection of P. gingivalis in gingival crevicular fluid. Screening of a proteolytic peptide substrate library, including

[Analysis of salivary protease spectrum in chronic periodontitis].

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OBJECTIVE This study aimed to investigate the difference in salivary protease expression in patients with chronic periodontitis and normal individuals. METHODS The stimulating saliva in patients with chronic periodontitis and normal individuals were collected. Protein chip technology was adapted to

[Proteases and their inhibitors in rapidly progressive and in juvenile periodontitis].

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The purpose of this work was to study the elastase content of PMNs, the elastase alpha1-protease inhibitor complex, and the protease inhibitors in the plasma of patients with periodontal disease as compared with healthy subjects. We examined 11 patients with localized juvenile periodontitis (LJP),

Gingival crevicular fluid levels of protease-activated receptors type 1 and type 2 in diabetic patients with periodontitis.

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OBJECTIVE Protease activated receptor type 1 (PAR1 ) seems to play a role in periodontal repair, while PAR2 is associated with periodontal inflammation. As diabetes is a known risk factor for periodontal disease, the aim of this study was to evaluate the influence of type 2 diabetes on PAR1 and PAR2

Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis.

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OBJECTIVE There are indications that acute myocardial infarction (AMI) may have an effect on the oral environment, which is reflected in the expression of salivary and gingival proteinases. According to our knowledge, no studies have been carried out to investigate the effect of AMI on the

Long-term monitoring of adult periodontitis patients in supportive periodontal therapy: correlation of gingival crevicular fluid proteases with probing attachment loss.

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The aim of this retrospective study was to determine if a chairside assay for neutral protease activity in gingival crevicular fluid (GCF) could provide an early indication of site-specific disease activity, as defined by probing attachment loss. Clinical measures and assay data were collected at

Analysis of in situ protease activity in chronic adult periodontitis patients: expression of activated MMP-2 and a 40 kDa serine protease.

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BACKGROUND Periodontitis is characterized by extensive destruction of the gingival tissues and associated supporting structures of the teeth. Although the pathogenesis of the various forms of this disease is not completely understood, host-derived proteases are believed to have an important role. In

The short-term effectiveness of non-surgical treatment in reducing protease activity in gingival crevicular fluid from chronic periodontitis patients.

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OBJECTIVE The aim of this study was to evaluate the short-term effect of non-surgical periodontal treatment on protease activity in gingival crevicular fluid (GCF) of patients with chronic periodontitis. METHODS After clinical examination, in which pocket probing depth, probing attachment level,

Expression of protease-activated receptors 1 and 2 in individuals with healthy gingiva and chronic periodontitis.

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UNASSIGNED Protease-activated receptors (PAR-1 and PAR-2) are found to be immensely exhibited in the periodontal tissues. These receptors are involved in the inflammatory and repair processes. Activation of PARs is mainly by the bacterial and endogenous enzymes. The aim of the study was to determine

Immunization of Macaca fascicularis against experimental periodontitis using a vaccine containing cysteine proteases purified from Porphyromonas gingivalis.

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BACKGROUND Periodontitis is a common infectious disease to which Porphyromonas gingivalis has been closely linked, in which the attachment tissues of the teeth and their alveolar bone housing are destroyed. We conducted a study to determine if immunization using a purified antigen could alter the

Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis.

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The tissue destruction seen in chronic periodontitis is commonly accepted to involve extensive upregulation of the host inflammatory response. Protease-activated receptor 2 (PAR-2)-null mice infected with Porphyromonas gingivalis did not display periodontal bone resorption in contrast to

Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis.

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OBJECTIVE Elastase is carried into the oral cavity by gingival crevicular fluid (GCF) from periodontal lesions. Our study investigated the regulation of elastase activity by secretory leukocyte protease inhibitor (SLPI) and the possible action of another GCF protease on this protective salivary

[Expressions of protease-activated receptors in human gingival fibroblasts and its functions in periodontitis].

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OBJECTIVE To investigate the expression types of protease-activated receptors(PAR) in human gingival fibroblasts(HGF) and the functions of PAR in periodontitis. METHODS Primary HGF were cultured.Reverse transcription PCR(RT-PCR) was used to detect the expression of PAR in HGF. Recombinant gingipain

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