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Strana 1 od 167 výsledky
Effect of filtering amphotericin B infusions on the incidence and severity of phlebitis and selected adverse reactions.
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This study evaluated the effectiveness of filtering amphotericin B (ampho B) on the incidence and severity of drug-related complications. Fifteen males receiving ampho B via peripheral vein infusion participated in this randomized, double-blind study. Each patient had his dose of ampho B diluted in
[Methods of preventing phlebitis induced by infusion of fosaprepitant].
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At our hospital, we use aprepitant for nausea and vomiting when administering highly emetic anticancer agents, according to "Guidelines for the Appropriate Use of Antiemetic Agents" given by the Japan Society of Clinical Oncology. We initiated the intravenous administration of fosaprepitant for
Orbital hemorrhage and eyelid ecchymosis in acute orbital myositis.
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We examined two patients with acute orbital myositis associated with orbital hemorrhage and eyelid ecchymosis. Both patients were young women (aged 22 and 30 years) who had painful proptosis, diplopia, and computed tomographic evidence of single extraocular muscle involvement with spillover of
A clinical and pharmacokinetic phase I study of 1,2,4-triglycidylurazol (TGU, NSC 332488).
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Twenty-six patients with advanced malignancies received TGU given as an intravenous (i.v.) bolus in physiological saline at 3 weekly intervals. The starting dose was 30 mg/m2 with standard graded escalations to 900 mg/m2. Myelosuppression occurred at 800 mg/m2, with a mean nadir of 2.0 +/- 0.8 X
A phase II trial of raltitrexed (Tomudex) in advanced pancreatic and biliary carcinoma.
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OBJECTIVE
To evaluate the impact of raltitrexed (Tomudex) on the quality of life in a multicenter, phase II study in advanced pancreatic and biliary carcinomas.
METHODS
Forty-six patients with advanced, histologically proven pancreatic (n = 37, 80.4%) or biliary (n = 9, 19.6%) carcinoma received 3
[Propofol in comparison with etomidate for the induction of anesthesia].
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In the present study propofol and etomidate were compared with respect to the effects on the cardiovascular system and its side effects in 100 patients ASA grade I-IV. Anaesthesia was induced with 2.2 mg kg-1 body weight propofol. Supplemented with opioids and benzodiazepins the dose diminished to
Comparing local tumescent anesthesia and spinal anesthesia methods during and after endovenous radiofrequency ablation of vena saphena magna that includes mini-phlebectomy operations
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Background: Local or spinal anesthesia methods can be used during radiofrequency ablation (RFA) of the great saphenous vein. There is a gap in the literature regarding comparing and contrasting the side effects of the mentioned two
Miconazole for treatment of disseminated coccidioidomycosis. Unfavorable experience.
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Miconazole at dosages up to 30 mg/kg/day was given intravenously to seven patients with complicated courses of disseminated coccidioidomycosis. Six had received treatment with amphotericin B previously and five of these patients could be evaluated for the efficacy of the treatment. In three patients
Clinical aspects of venous thrombophilia.
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Venous thrombophilia is the result of clotting changes namely of a hypercoagulable state together with blood flow and vessel wall changes. There is no need for all these components to be present in order for thrombosis to occur. As the matter of fact, thrombosis may occur even if only one of these
Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. The Multicenter Study Group.
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The toxicity and hematologic effects of Escherichia coli-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) were studied in 58 treatment cycles in Japanese patients with advanced malignancy as a phase I/II clinical trial. rhGM-CSF in doses from 30 to 250
[Clinical analysis of amphotericin B in the treatment of invasive fungal infections in 121 patients with hematologic diseases].
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OBJECTIVE
To observe the efficacy and safety of amphotericin B for treatment of invasive fungal infections (IFI) in patients with hematologic diseases.
METHODS
121 patients were given amphotericin B 5 -50 mg/d for 5 - 101 d with a median of 19 d.
RESULTS
The clinical efficacy rate was 67.3%, and
[Analysis of adverse reactions and pharmacovigilance research to parenterally administered shuxuening].
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Parenterally administered Shuxuening is a commonly used Chinese medicine. There is a need to understand the characteristics of adverse drug reactions (ADRs) to it. 9 601 ADR cases reports were collected from the national adverse drug reaction monitoring center reported between January, 2005 and
Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: a prospective randomized crossover trial.
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We have conducted a randomized crossover comparative trial of a single-dose course of disodium (3-amino-1-hydroxypropylidene) bisphosphonate pentahydrate (pamidronate) and plicamycin in 48 patients with a first occurrence of tumor-related hypercalcemia. All patients had hypercalcaemia-associated
IgG4-related hypophysitis presenting as a pituitary adenoma with systemic disease.
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Hypophysitis is a rare inflammatory disorder that can mimic a pituitary tumor clinically or radiologically. Furthermore, immunoglobulin G4 (IgG4)-related systemic disease is only a just recently characterized disorder. It can manifest as a systemic disease involving multiple organs, including the
[IgG4-associated diseases mainly with auricular symptoms: a case report and literature review].
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Summary To analyze the clinical features of IgG4-related diseases mainly with otologic manifestations and investigate diagnosis and treatment of IgG4-related diseases. We report the clinical course and diagnosis and treatment process of a case of IgG4-related disease misdiagnosed as chronic
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