Piperidine / bolesť hlavy

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also

Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists

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FIELD OF INVENTION The invention relates to piperidine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists useful in the treatment of diseases and disorders responsive to antagonism of NMDA receptors. BACKGROUND OF THE INVENTION Many of the physiological and pathophysiological effects of the

Methods for preventing headaches

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FIELD OF THE INVENTION The current invention provides methods for the inhibition of headaches in humans, particularly post-menopausal women. BACKGROUND OF THE INVENTION Headaches have been a common malady in humans throughout history, and today still remain a major problem and source of suffering

Substituted prolines / piperidines as orexin receptor antagonists

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BACKGROUND Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus

Substituted prolines/piperidines as orexin receptor antagonists

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BACKGROUND Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus

Substituted prolines/piperidines as orexin receptor antagonists

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BACKGROUND Orexins are a family of homologous peptides including species orexin A, or OR-A, and orexin B, or OR-B. Orexin A is a 33 amino acid peptide and orexin B is a 28 amino acid peptide (Sakurai T. et al., Cell (1998), 92, 573-585). Orexins are produced in neurons of the lateral hypothalamus

1',4'-Dihydro-1-methyl-spiro[piperidine and pyrolidine-2,3'(2'H)quinoline] c

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The present invention relates to novel spiro-compounds having pharmaceutical activities as well as novel processes for their production. More particularly, the present invention relates to novel spiro-compounds of the formula: ##SPC2## Wherein n stands for an integer 1 or 2, and the corresponding

CGRP receptor antagonist

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BACKGROUND OF THE INVENTION The disclosure generally relates to the compound (R)--N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperaz- in-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-- carboxamide (Compound I or the compound of formula I), including

Heterocyclic amines having central nervous system activity

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BACKGROUND OF THE INVENTION The present invention is directed toward tricyclic nitrogen containing compounds, heterocyclic amines, having anxiolytic and anti-depressant activity. These new compounds are suitable for treating central nervous system disorders including schizophrenia, Parkinson's

Heterocyclic amines having central nervous system activity

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BACKGROUND OF THE INVENTION The present invention is directed toward tricyclic nitrogen containing compounds, heterocyclic amines, having anxiolytic and anti-depressant activity. These new compounds are suitable for treating central nervous system disorders including schizophrenia, Parkinson's

Heterocyclic amines having central nervous system activity

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BACKGROUND OF THE INVENTION The present invention is directed toward tricyclic nitrogen containing compounds, heterocyclic amines, having anxiolytic and anti-depressant activity. These new compounds are suitable for treating central nervous system disorders including schizophrenia, Parkinson's

piperidine/bolesť hlavy

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists

4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists

Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists

Methods for preventing headaches

Substituted prolines / piperidines as orexin receptor antagonists

Substituted prolines/piperidines as orexin receptor antagonists

Substituted prolines/piperidines as orexin receptor antagonists

1',4'-Dihydro-1-methyl-spiro[piperidine and pyrolidine-2,3'(2'H)quinoline] c

CGRP receptor antagonist

Heterocyclic amines having central nervous system activity

Heterocyclic amines having central nervous system activity

Heterocyclic amines having central nervous system activity

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