thalassemia/draslík

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Potassium permeability in -thalassemia minor red blood cells.

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The intracellular content of K(+) in thalassemia minor red blood cells is markedly reduced after incubation in autologous serum for 24 hr at 37 degrees C. There is no compensatory increase in intracellular Na(+) concentration of the cell thus reduced. This change is due to an acquired increase in

Evaluation of some essential element levels in thalassemia major patients in Mosul district, Iraq.

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OBJECTIVE To evaluate the levels of some essential elements in thalassemic patients in Mosul, Iraq. METHODS One hundred and five thalassemic blood transfusion dependent children, 2.5-18 years of age attending Ibn-Al-Atheer teaching hospital in Mosul City, Iraq, during 2005, were used in this study.

Renal abnormalities in patients with sickle cell-beta thalassemia.

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We examined renal abnormalities in Greek patients with sickle-cell beta thalassemia (S-beta thal). A total of 17 patients aged 16-59 years suffering from S-beta thal and 17 age- and sex-matched healthy controls were studied. In all individuals we carried out a detailed study of renal function

Asymptomatic actinomycosis in a girl with thalassemia major.

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We present a rare case of lung actinomycosis in a girl with thalassemia major with a competent immunological status. Chest computed tomography scans showed high intensity nodules in the right lower lung. Diagnosis was confirmed by revealing of actonomycetes from the staining of bronchoalveolar

A prospective study of tubular dysfunction in pediatric patients with Beta thalassemia major receiving deferasirox.

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BACKGROUND Beta thalassemia major is a lifelong transfusion-dependent disorder. Transfusion-dependent thalassemia patients are prone to develop renal dysfunction due to iron overload, chronic anemia, and/or chelation therapy. METHODS In this prospective study, thalassemia patients who fitted

Influence of hemoglobin precipitation on erythrocyte metabolism in alpha and beta thalassemia.

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Certain aspects of the metabolism of centrifuged young and old erythrocytes in hemoglobin H disease have been examined and compared with similar studies of beta thalassemia and normal cells. Glycolysis, hexose monophosphate shunt activity (HMPS), potassium flux, and glutathione (GSH) content were

Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.

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Abnormal deposits of free iron are found on the cytoplasmic surface of red blood cell (RBC) membranes in beta-thalassemia. To test the hypothesis that this is of importance to RBC pathobiology, we administered the iron chelator deferiprone (L1) intraperitoneally to beta-thalassemic mice for 4 wk and

Hematological and biochemical status of Beta-thalassemia major patients in Bangladesh: A comparative analysis.

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BACKGROUND Thalassemia is one of the most common hereditary disorders and Beta-thalassemia major is its severe form. The present study is concerned with the analysis of liver function, thyroid function and estimation of critical serum ions as well as hematological characteristics in beta-thalassemia

Hematological and biochemical evaluation of β-thalassemia major (βTM) patients in Gaza Strip: A cross-sectional study.

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In Gaza Strip, Palestine, β-thalassemia is a major public health problem where more than 300 β-thalassemia major (βTM) patients are currently being managed at governmental hospitals. We set up to evaluate the hematological and biochemical aspects of our βTM patients at the Gaza

A Novel Variant with Positive Natural Selection Influenced Hb A2 Levels in Chinese Individuals with β-Thalassemia.

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β-Thalassemia (β-thal) is the most common inherited hemolytic anemia worldwide. Elevated Hb A2 is a mark of β-thal carriers. The aim of this study was to identify the pathogenic variants associated with the Hb A2 levels. One thousand and thirty β-thal carriers were recruited for this study. Using

Cortisol response to low dose versus standard dose (back-to-back) adrenocorticotrophic stimulation tests in children and young adults with thalassemia major.

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BACKGROUND Thalassemia major patients with repeated blood transfusion have high prevalence of endocrinopathies due to iron overload. METHODS We examined the adrenocortical function in 23 thalassemic patients (10 children and 13 young adults) aged 8-26 years. Serum cortisol and dehydroepiandrosterone

Renal Hemosiderosis among Iranian Transfusion Dependent β-Thalassemia Major Patients.

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Background: In recent years, the success in management of thalassemic patients, has allowed for some previously unrecognized complications including renal abnormalities to emerge. This prospective study aimed to investigate kidney iron overload by means of MRI T2* and also renal function based on

Urinary early kidney injury molecules in children with beta-thalassemia major.

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BACKGROUND The aim of this study was to investigate novel urinary biomarkers including N-acetyl-β-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and liver-type fatty acid binding protein (L-FABP) in children with β-thalassemia major

Early markers of renal dysfunction in patients with beta-thalassemia major.

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Studies of renal involvement in thalassemia syndromes have been varied and few. The most important cause of mortality and morbidity in these patients is organ failure due to iron deposition. We report here a cross-sectional study carried out between February 2005 and February 2006 on all

Renal function in pediatric patients with beta-thalassemia major.

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In patients with beta-thalassemia major, the most important cause of mortality and morbidity is organ failure due to deposits of iron. In this study, the nature of the kidney injury and possible pathogenetic factors were investigated. Seventy children with beta-thalassemia major and 14 age and

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