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ubiquinone/zápal

Odkaz sa uloží do schránky
Strana 1 od 96 výsledky

Mitochondrial-targeted ubiquinone alleviates concanavalin A-induced hepatitis via immune modulation.

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Despite knowledge regarding the effects of antioxidants in ameliorating oxidative damage, evidence concerning their effects on activated immune cells is lacking. Here, a concanavalin A (Con A)-induced hepatitis mouse model was used to investigate the protective effects and immune

Coenzyme Q10 level in plasma of children with inflammatory process.

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Using a newly developed method by HPLC with ultraviolet detection we measured plasma coenzyme Q10 (CoQ10) level in group of 43 children (19 females and 24 males: ages 1 month-9 years) with an acute inflammatory process. The results for coenzyme Q10 were expressed as molar concentration (mumol/l

Synergistic effects of tocopherol, tocotrienol, and ubiquinone in indomethacin-induced experimental gastric lesions.

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Nonsteroidal anti-inflammatory drugs and their adverse effects on the gastric mucosa are yet another set of unresolved medical problems. This study examined the effects of various antioxidants on several gastric parameters after a single exposure to indomethacin. Forty-eight male rats of the
Since the last decade, nanodispersed drug delivery systems gain increasingly more importance for therapeutic research fields. The forced transport to the centers of inflammation is supposed to take advantage as a novel strategic approach. Thus, the focus of this study was to investigate the

[Effect of ubiquinone and other scavengers on alterations caused by oxidative stress].

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In the development of several diseases the oxidative stress is a significant aetiological or important pathogenetic factor. Its significance has been proved in the pathogenesis of several diseases, among them in arteriosclerosis and reperfusion, in inflammation and immunological disorders, as well

The effect of ubiquinone on functional recovery and morphometric indices of sciatic nerve regeneration.

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A common cause of peripheral nerve injury is trauma. The positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. In this experiment, the effect of intraperitoneal administration of ubiquinone (CoQ10) on an acute experimentally sciatic nerve
The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1β (IL-1β) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures. Wistar rats were intraperitoneally administered with either

Nano ubiquinone: Promising candidate for treatment of renal toxicity induced by over dose of paracetamol.

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Over doses of Paracetamol (panadol; acetaminophen) can cause life-threatening renal damage. This study compared the impact of nano-ubiquinone (Nubiq) with native ubiquinone (ubiq) reducing damage induced by Paracetamol-toxicity in rats. Paracetamol treatment produced an elevation in serum urea, uric

Hypothalamic digoxin, hemispheric chemical dominance, and inflammatory bowel disease.

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The isoprenoid pathway produces three key metabolites--endogenous digoxin, dolichol, and ubiquinone. It was considered pertinent to assess the pathway in inflammatory bowel disease (ulcerative colitis and regional ileitis). Since endogenous digoxin can regulate neurotransmitter transport, the

Oxidative stress induced inflammation initiates functional decline of tear production.

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Oxidative damage and inflammation are proposed to be involved in an age-related functional decline of exocrine glands. However, the molecular mechanism of how oxidative stress affects the secretory function of exocrine glands is unclear. We developed a novel mev-1 conditional transgenic mouse model

Anti-inflammatory effects of CoQ10 and colorless carotenoids.

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BACKGROUND CoQ10 (ubiquinone, coenzyme Q10) and carotenoids are popular antioxidants used in many skin care products to protect the skin from free radical damage. OBJECTIVE To evaluate the effects of CoQ10 and colorless carotenoids on the production of inflammatory mediators in human dermal

Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats.

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As a class, hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors can potentially cause skeletal myopathy. One statin, cerivastatin, has recently been withdrawn from the market due to an unacceptably high incidence of rhabdomyolysis. The mechanism underlying statin-induced myopathy is

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

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Chronic alcohol-induced liver disease results in inflammation, steatosis, and increased oxidative and nitrosative damage to the mitochondrion. We hypothesized that targeting an antioxidant to the mitochondria would prevent oxidative damage and attenuate the steatosis associated with alcoholic liver
This study utilizes 2D-DIGE (difference gel etrophoresis), isotope-coded protein labeling and biochemical assays to characterize protein alteration in ulcerative colitis (UC) and Crohn's disease (CD) in human epithelial cell and mucosal biopsies in inflammatory bowel disease (IBD)-affected patients.

Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function.

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Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction. There are three main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress, and mitochondrial dysfunction. Inflammation induces activation of nuclear factor kappa B, activator protein 1, and
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