Preeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2
Ključne besede
Povzetek
Datumi
Nazadnje preverjeno: | 04/30/2020 |
Prvič predloženo: | 01/19/2020 |
Predviden vpis oddan: | 01/22/2020 |
Prvič objavljeno: | 01/26/2020 |
Zadnja posodobitev oddana: | 05/20/2020 |
Zadnja posodobitev objavljena: | 05/21/2020 |
Dejanski datum začetka študija: | 01/19/2020 |
Predvideni datum primarnega zaključka: | 05/19/2020 |
Predvideni datum zaključka študije: | 05/19/2020 |
Stanje ali bolezen
Intervencija / zdravljenje
Diagnostic Test: Pentraxin 3 ; new biomarker
Diagnostic Test: Lipoprotein-associated phospholipase A2 ; new biomarker
Faza
Skupine rok
Roka | Intervencija / zdravljenje |
---|---|
healthy pregnant women Blood samples taken from 40 healthy pregnant women will be obtained by taking patient consent forms and storing their serum at -80 degrees. Then, serum Pentraxin 3 and Lp-PLA2 levels will be checked in these blood by ELISA method.
this group will be the control group. | |
preeclamptic pregnant women Blood samples taken from 40 preeclamptic pregnant women will be obtained by taking patient consent forms and storing their serum at -80 degrees. Then, serum Pentraxin 3 and Lp-PLA2 levels will be checked in these blood by ELISA method.
this group will be the study group. |
Merila upravičenosti
Starost, primerna za študij | 18 Years Za 18 Years |
Spol, upravičen do študija | Female |
Metoda vzorčenja | Probability Sample |
Sprejema zdrave prostovoljce | Da |
Merila | Inclusion Criteria: - pregnant women diagnosed with preeclampsia; The blood pressure and proteinuria (at least ≥ 300 mg in urine for 24 hours) will be established before the 20th week of gestation in normotensive pregnancies with an interval of 6 hours. - Those who have Grand mal convulsions; other causes of convulsions and exclusion of coma were defined as having seizures for the first time after 20 weeks of gestation and 48-72 hours after delivery. - The diagnosis of HELLP syndrome will be confirmed by intravascular hemolysis. (Abnormal peripheral smear and / or abnormal bilirubin values), high liver enzymes (high serum aspartate transaminase levels [AST], alanine transferase [ALT] and lactate dehydrogenase [LDH] üst 2 upper level) and low platelet count (<100 000 / mm3) - healthy pregnant women without additional disease for the control group Exclusion Criteria: - Maternal diabetes - Kidney disease - Cardiovascular disease - Neurological disease - drug use history - Hematological and immunological disease - The presence of any infection - Fetal anomaly - In utero dead fetus |
Izid
Primarni izidni ukrepi
1. study group [1 week]
2. control group [1 week]