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Chemical and Pharmaceutical Bulletin 2005-Mar

An antibacterial biphenyl derivative from Garcinia bancana MIQ.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Povezava se shrani v odložišče
Vatcharin Rukachaisirikul
Wanpen Naklue
Yaowapa Sukpondma
Souwalak Phongpaichit

Ključne besede

Povzetek

From the methanol extract of the twigs and leaves of Garcinia bancana MIQ., one new biphenyl derivative (1), was isolated and characterized along with nine known compounds; garcinol, isogarcinol, (-)-mellein, 8-hydroxy-6-methoxy-3-n-pentylisocoumarin, blumenol C O-beta-D-glucoside, quercetin 3-O-alpha-L-rhamnoside, kaemferol 3-O-alpha-L-rhamnoside, lupeol and stigmasterol. Their structures were determined by analysis of 1D and 2D NMR data and comparison of spectral data and physical data with those previously reported. The antibacterial activity against methicillin-resistant Staphylococcus aureus was evaluated. Garcinol showed the lowest minimum inhibition concentration (MIC) at 16 microg/ml while compound 1 exhibited weaker activity with MIC value of 64 microg/ml.

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