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Bioorganic and Medicinal Chemistry Letters 2011-Jan

Ring A-seco triterpenoids with antibacterial activity from Dysoxylum hainanense.

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Xiu-Feng He
Xiao-Ning Wang
Sheng Yin
Lei Dong
Jian-Min Yue

Ključne besede

Povzetek

Five new ring A-seco triterpenoids, dysoxyhainic acids F-J (1-5), along with a known ring A-seco triterpenoid koetjapic acid (6) were isolated from the twigs and leaves of Dysoxylum hainanense. Their structures were established on the basis of extensive spectroscopic analysis. Antimicrobial activity of all the compounds against fungi and bacteria were tested. Compounds 2-4 and 6 exhibited significant antimicrobial activity against Gram-positive bacteria, and the antibacterial SAR (structure-activity relationship) was also briefly discussed.

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