Magnolol induces adipogenic differentiation in human skin.

The skin adipose tissue participates in energy storage, thermogenesis, endocrine secretion, fibrosis and scarring, and innate immune defense.¹ Furthermore, the facial subcutaneous fat is important for skin aging such as elasticity and wrinkle formation.^2,3 The subcutaneous layer as well as epidermal-dermal layer is modified with age through changes in its thickness, preadipocytes' differentiation, and size of adipocytes.⁴ It has been established that the age-dependent changes of fat layer are associated with our health, body shape and skin condition including metabolic diseases, obesity, and facial aging.