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aconitase/dental caries
Povezava se shrani v odložišče
9 rezultatov
Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy.
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Prijava / prijava
Transgenic mice (TG) were used to define mitochondrial oxidative stress and cardiomyopathy (CM) induced by zidovudine (AZT), an antiretroviral used to treat HIV/AIDS. Genetically engineered mice either depleted or overexpressed mitochondrial superoxide dismutase (SOD2(+/-) KOs and SOD2-OX,
Identification of stress-responsive genes in Streptococcus mutans by differential display reverse transcription-PCR.
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Prijava / prijava
Streptococcus mutans, which causes dental caries in the human oral cavity and occasionally causes infective endocarditis in the heart, withstands adverse environmental stress through diverse alterations in protein synthesis. Differential gene expression in response to environmental stress was
Inhibition of DNA synthesis in mouse lymphosarcoma LS/BL cells by fluorocitrate.
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Prijava / prijava
Fluorocitrate is a specific inhibitor of aconitase activity (EC 4.2.1.3). It causes an inhibition of citric acid cycle reactions and consequently reduces the oxygen consumption, as well as the total volume of oxidative phosphorylations. Experiments using 3H-thymidine incorporation into mouse
The ferritin genes: their response to iron status.
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Prijava / prijava
Iron is a required nutrient which, at high concentrations, can peroxidize cell lipids and other cellular components. To prevent excess iron from damaging cells, it is stored in ferritin, which consists of a shell of protein subunits of two related types, H (heavy) and L (light), surrounding a cavity
The crystal structure of Fe₄S₄ quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.
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Prijava / prijava
Quinolinate synthase (NadA) is a Fe4S4 cluster-containing dehydrating enzyme involved in the synthesis of quinolinic acid (QA), the universal precursor of the essential nicotinamide adenine dinucleotide (NAD) coenzyme. A previously determined apo NadA crystal structure revealed the binding of one
Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer.
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Prijava / prijava
Mitochondrial processing peptidase (MPP), which is composed of heterodimeric alpha-MPP and beta-MPP subunits. It specifically recognizes mitochondrial preproteins and removes their basic N-terminal signal prepeptides. In order to elucidate the spatial orientation of the preproteins toward MPP, which
An in vitro and in vivo study of plasma treatment effects on oral biofilms.
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Prijava / prijava
Management of dental plaque/biofilms is critical to maintain oral health. The objective of this study is to investigate the treatment effects of non-thermal atmospheric gas plasmas on oral biofilm formation and recovery under in vitro and in vivo conditions. Streptococcus mutans
GroEL/GroES-mediated folding of a protein too large to be encapsulated.
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Prijava / prijava
The chaperonin GroEL binds nonnative proteins too large to fit inside the productive GroEL-GroES cis cavity, but whether and how it assists their folding has remained unanswered. We have examined yeast mitochondrial aconitase, an 82 kDa monomeric Fe(4)S(4) cluster-containing enzyme, observed to
The ferritins: molecular properties, iron storage function and cellular regulation.
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Prijava / prijava
The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester the element gives ferritin the dual functions of iron detoxification and iron reserve. The importance of these functions is emphasised by ferritin's ubiquitous distribution among living species.
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