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3 rezultatov
Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV).
METHODS
Compounds were tested against Junin virus (JUNV), an arenavirus agent of Argentine haemorrhagic fever, and dengue virus (DENV), a
Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective antiviral activity against the HF causing arenavirus Junin virus (JUNV) of the
Structure-activity relationships for substituted 9-oxo-9,10-dihydroacridine-4-acetic acids: analogues of the colon tumour active agent xanthenone-4-acetic acid.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
A series of 9-oxo-9,10-dihydroacridine-4-acetic acids (acridone-4-acetic acids) were prepared by Jourdan-Ullmann condensation of 2-halobenzoic acids with 2-aminophenylacetic acids, followed by H2SO4-induced cyclodehydration of the resulting 2-[2-(carboxymethyl)phenylamino]benzoic acids. These were
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