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Seizures with neuroleptics and antidepressants.

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Seizures remain among the most serious side effects of psychotropic drugs. The authors review the literature associating neuroleptic and antidepressant medications with seizures, discussing the relative "seizurogenicity" of different medications, risk factors for seizures, and drugs of choice for

Effects of new neuroleptics, isofloxythepin and zotepine, on post-decapitation convulsions and prolactin secretion in rats.

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Oral administration of isofloxythepin (0.5-8.0 mg/kg) inhibited decapitation convulsions in a dose-dependent manner as shown by decreasing the incidence and shortening the convulsion's duration, the effects continuing until 24 hr after administration. Zotepine (8, 16 mg/kg, SC) also decreased the

High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.

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Antipsychotic-induced extrapyramidal side effects have a negative impact on treatment for mental illness. Acute dystonic reactions are uncomfortable and frightening to the patient, and often lead to early discontinuation of drug therapy and worsened long-term outcome. The lower propensity of the

[The effect of neuroleptics and neuroleptic/analgesic combinations on the sensitivity to seizures in mice].

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Combinations of neuroleptic and morphine-like analgesic drugs are used alone for minor surgery or as anesthetic premedication. While morphine-like analgesics given in the therapeutic dose range show anticonvulsant properties, there is evidence indicating that neuroleptics are rather proconvulsant.

Inhibition of post-decapitation convulsions in the rat by dibenzothiepin neuroleptics via alpha 1-adrenoceptor blockade.

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The mechanisms involved in inhibitory effects of isofloxythepin, a newly synthesized dibenzothiepin neuroleptic, on post-decapitation convulsions were studied in rats. Isofloxythepin (0.05-2.0 mg/kg s.c.) inhibited post-decapitation convulsions in a dose-dependent manner as shown by the decrease in

[Epileptic seizures during treatment with antidepressants and neuroleptics].

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Epileptic seizures are observed during treatment with antidepressants and neuroleptics more frequently than is the case for other neuroactive substances. Evidence from experimental and observational studies is mixed, suggesting an increased incidence of seizures for certain drugs, whilst other drugs

Antipsychotic medication and seizures: a review.

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Both first-generation and second-generation antipsychotic medications can lower the seizure threshold, increasing the chances of seizure induction. This article reviews the published literature concerning the seizure-lowering effects of first- and second-generation antipsychotic medication.

Seizure activity associated with antipsychotic therapy.

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Approximately one percent of patients receiving antipsychotic medications develop seizure activity. In addition, approximately seven percent of epileptic patients develop chronic psychosis requiring antipsychotic treatment. A history of antipsychotic-induced seizures in patients exhibiting florid

Enhancement of drug withdrawal convulsion by combinations of phenobarbital and antipsychotic agents.

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Antipsychotic agents which are considered to depressive to the central nervous system (CNS) but free of dependence liability were used in combination with barbiturates or tranquilizers to study the physical dependence liability in the so-enhanced CNS depression. In the study of physical dependence

Antipsychotic medications and seizures.

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This chapter will review the in vitro laboratory as well as animal and clinical studies of the comparative effect of antipsychotic medications on the seizure threshold. It will critically examine current theories relating antipsychotic medications and seizure induction. Finally, it will provide

Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder.

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OBJECTIVE The aim of the study was to highlight the diagnostic difficulties occurring when hyponatremia presents concurrently with neuroleptic malignant syndrome (NMS). Diagnostic issues in the differentiation between hyponatremia and NMS are discussed. METHODS A case of dilutional hyponatremia (DH)

[Cerebral seizures in neuroleptic therapy].

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Basing on a review of the literature and on own research, the authors examine the incidence rate of convulsions under neuroleptic treatment. In addition, the authors go into the neurophysiological and neuropharmacological mechanisms of the convulsive action of neuroleptics. An attempt is made to

Antipsychotic drugs and seizures.

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The authors examine the clinical problem of which antipsychotic drug to use when antipsychotics are indicated in patients with a seizuire disorder or who are susceptible to seizures. While definitive answers to this problem are still unknown, guidelines are offered for antipsychotic drug use in this

The impact of neuroleptic medication on seizure threshold and duration in electroconvulsive therapy.

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BACKGROUND In most patients diagnosed with psychotic depression or schizophrenia and treated with electroconvulsive therapy, parallelly administered antipsychotic medication cannot be stopped. Antipsychotic drugs can influence both seizure threshold and seizure activity in different

Antipsychotic drug use and the risk of seizures: follow-up study with a nested case-control analysis.

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OBJECTIVE To investigate the association between antipsychotic drug use and the development of first-time seizures in patients with schizophrenia, affective disorders, or dementia. METHODS We used data from the UK-based Clinical Practice Research Datalink database to conduct a follow-up study with a

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