artemisine/malarija

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Short report: High prevalence of multidrug-resistant Plasmodium falciparum malaria in the French territory of Mayotte.

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Prijava / prijava

A drug-resistance survey was conducted in the French territory of Mayotte in the Comorian Islands in the Indian Ocean where malaria is endemic. A high prevalence of resistant Plasmodium falciparum parasites was observed, not only to chloroquine (88%) and pyrimethamine (99%), but more surprisingly to

Cerebral malaria and multi-organ dysfunction in an adult woman with Plasmodium falciparum infection imported from Cameroon: a case report

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Prijava / prijava

Malaria is one of the most life-threatening parasitic diseases caused by the protozoa of the genus Plasmodium, occurring in the tropical and subtropical regions. Misdiagnosed infection can progress to a wide range of life-threatening pathologies, including severe anemia and cerebral malaria which

Top five medical innovations in China mainland since Xinhai revolution [1911]: results of AME survey-002.

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Prijava / prijava

OBJECTIVE This survey aims to scrutinize important medical innovations in Chinese mainland since Xinhai (Hsin-hai) revolution in 1911, which marked the end of Manchurian imperial rule and the beginning of China's republican era. METHODS An online cross-sectional survey was carried out during the

Drug and vaccine development.

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Prijava / prijava

Some of the activities in chemotherapeutic research and vaccine development which WHO has initiated, participated, coordinated or funded are reviewed. WHO has interests in research, particularly, although by means exclusively, in all the communicable diseases and in applied vaccinology. Examples are

Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.

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Prijava / prijava

Halofantrine (HF) is used in the treatment of uncomplicated multidrug-resistant Plasmodium falciparum malaria. Severe cardiotoxicity has been reported to be correlated with high plasma concentrations of HF but not with that of its metabolite N-debutylhalofantrine. The aim of this study was to

[Pharmacodynamics of dihydroartemisinine against Plasmodium berghei in mice].

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Prijava / prijava

Dihydroartemisinine (DHA) is a derivative of qinghaosu(artemisine), which is an antimalarial drug. DHA was given to mice inoculated with Plasmodium berhgei ANKA strain by intramuscular injection. Within proper dose range, the dose-effect and time-effect curves of DHA against the malaria can be

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