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8 rezultatov
Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
This study was designed to evaluate the neuroprotective effect of the cannabinoid agonist WIN-55212 after inducing acute severe asphyxia in newborn rats. The left common carotid artery was ligated in anaesthetised 7-day-old Wistar rats, which were then asphyxiated by inhaling 100% nitrogen for 10
Interpretation of Cannabis Findings in the Hair of Very Young Children: Mission Impossible.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Hair has been suggested since the middle of the 90's to be a suitable matrix to document repetitive exposure to cannabis. Because it is possible to detect Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) in cannabis smoke, the identification of the metabolite,
[The cannabinoid system and its importance in the perinatal period].
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The cannabinoid system has been recently described, including the endogenous ligands, mainly arachidonic acid derivatives, and their specific receptors. Endocannabinoids are involved in the modulation of synaptic transmission, through which they exert their psychoactive, motor and antinociceptive
Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia-Ischemia.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
In the process of neonatal encephalopathy, oxidative stress and neuroinflammation have a prominent role after perinatal asphyxia. With the exception of therapeutic hypothermia, no therapeutic interventions are available in the clinical setting to target either the oxidative stress or inflammation,
Other agents. Phencyclidine, marijuana, hallucinogens, inhalants, and anticholinergics.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Acute phencyclidine intoxication causes psychosis and a myriad of other symptoms and signs, some life-threatening. Anticholinergic poisoning is also a medical emergency, often requiring an intensive care unit. Marijuana and hallucinogens have rarely, if ever, resulted in direct overdose death, but
Cannabinoids: well-suited candidates for the treatment of perinatal brain injury.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Perinatal brain injury can be induced by a number of different damaging events occurring during or shortly after birth, including neonatal asphyxia, neonatal hypoxia-ischemia and stroke-induced focal ischemia. Typical manifestations of these conditions are the presence of glutamate excitoxicity,
The cannabinoid WIN 55212-2 mitigates apoptosis and mitochondrial dysfunction after hypoxia ischemia.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Perinatal hypoxia-ischemia has significant mortality and morbidity due to there is still no specific treatment as a consequence of the complexities of hypoxic-ischemic pathophysiology. The aim of this work was to evaluate the effects of the cannabinoid agonist WIN 55212-2 on apoptotic cell death and
Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal brain lesions due to the complexity of neonatal hypoxic-ischemic pathophysiology, the
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