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Stran 1 iz 39 rezultatov
Pharmaceutical composition for treating spinocerebellar ataxia
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TECHNICAL FIELD
The present invention relates to a pharmaceutical composition for treating spinocerebellar ataxia (or atrophy, degeneration) or multiple system atrophy, or for improving ataxia or equilibrium disturbance.
BACKGROUND ART
Spinocerebellar ataxia (SCA) includes neurodegeneration diseases
Remedies for spinocerebellar ataxia and compositions for treating spinocerebellar ataxia
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This is a 371 of PCT/JP99/02971 field Jun. 3, 1999.
Technical Field
The present invention relates to a remedy for treatment of spinocerebellar degeneration comprising D-cycloserine, D-serine or D-serine ester as an active ingredient, a composition for treatment of spinocerebellar degeneration
Activators of class I histone deacetlyases (HDACs) and uses thereof
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FIELD OF THE INVENTION
The field of the invention pertains to activators of class I histone deacetylases and their uses in the treatment of neurological disorders.
BACKGROUND OF THE INVENTION
In a variety of neurodegenerative disorders such as ischemia and Alzheimer's disease (Hayashi et al.,
Use of famotidine and related compounds in the treatment of movement disorders
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INTRODUCTION
The present invention relates to methods of treating movement disorders which utilize famotidine or famotidine-related compounds. It is based, at least in part, on the discovery that famotidine ameliorates the symptoms and signs of Parkinson's Disease. In preferred embodiments of the
Method for treating neurodegeneration using a p38MAPK inhibitor
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jun. 23, 2014, is named 117735-02202_SL.txt and is 1,218 bytes in size.
INTRODUCTION
A-T
Desferrithiocin analogs and uses thereof
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BACKGROUND OF THE INVENTION
Nearly all life forms require iron as a micronutrient. However, the low solubility of Fe(III) hydroxide (K.sub.sp=1.times.10.sup.-39) (Raymond et al., "Coordination Chemistry and Microbial Iron Transport." Acc. Chem. Res. 1979, 12, 183-190), the predominant form of the
Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one
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BACKGROUND OF THE INVENTION
Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii) neuronal fate determination of NSC; (iii) survival and maturation of new neurons; and (iv) functional
1,7-naphthyridine derivatives
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of International Application No. PCT/EP2014/066123 having an international filing date of Jul. 28, 2014 and which claims benefit under 35 U.S.C. .sctn.119 to European Patent Application No. 13178373.0 filed Jul. 29, 2013. The
Benzisoxazoles
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BACKGROUND OF THE INVENTION
Now it has been shown that the present compounds stimulate neurogenesis from neural stem cells (NSCs). Neurogenesis occurs in the developing and adult brain. Conceptually, this process of neurogenesis can be divided into four steps: (i) proliferation of NSCs; (ii)
Imidazopyridine derivatives
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The present invention relates to compounds of general formula
##STR00002## wherein Ar is phenyl or pyridinyl; X.sup.1 is N or CH, X.sup.2 is N or CH, with the proviso that only one of X.sup.1 or X.sup.2 is N and the other is CH; R.sup.1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl
Isoquinoline derivatives
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The present invention relates to the use of compounds of general formula
##STR00002## wherein R.sup.1 is phenyl or pyridinyl, which are optionally substituted by halogen, cyano or lower alkyl substituted by halogen, or is dihydro-pyran-4-yl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is
Pro-neurogenic compounds
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TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
Pro-neurogenic compounds
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TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
Pro-neurogenic compounds
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TECHNICAL FIELD
This invention relates generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of newly formed neurons
Pro-neurogenic compounds
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TECHNICAL FIELD
This presently disclosed embodiments relate generally to the discovery of pro-neurogenic compounds capable of promoting neurogenesis and/or reducing neuronal cell death.
BACKGROUND
It is now accepted that the adult vertebrate brain fosters the birth and functional incorporation of
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