Age-matched controls with normal hearing or mild sensorineural hearing loss: 40 decibel or less in better hearing ear, and normal vestibular function

Moderate Sensorineural hearing loss: 41-60 decibel in the better hearing ear

Severe Sensorineural hearing loss: 61-80 decibel in the better hearing ear

Bilateral vestibulopathy: half with normal hearing, half with severe to profound sensorineural hearing loss

Hearing Loss, Sensorineural

Bilateral Vestibulopathy

Alzheimer Disease

Mild Cognitive Impairment

Longitudinal hearing, vestibular and cognitive follow-up

Longitudinal follow-up

University Hospital Antwerp

Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects

Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects: Correlation With Cortical Auditory Evoked Potentials and MRI Brain Volume Changes

Cognitive test adapted for hearing impaired subjects, minimum score is 200, maximum score is 800, higher scores indicate better cognitive performance

Ethisch Comité, UZA

Prof. dr. Vincent Van Rompaey, principal investigator

University Hospital, Antwerp

Universiteit Antwerpen

all patients at least 18 years of age who present bilateral vestibulopathy on vestibular investigations according to the Barany criteria

DFNA9 patients carrying the p.P51S mutation in COCH gene presenting bilateral vestibulopathy according to the Barany criteria

from all patients presenting bilateral vestibulopathy samples will be taken to investigate presence of p.P51S mutation in COCH

Bilateral Vestibular Deficiency

DFNA9

Radiology

vestibular test 1

vestibular test 2

vestibular evoked myogenic potentials to measure the function of otolith organs

vestibular evoked myogenic potentials

audiometry

CT and MR imaging of temporal bone

analysis of presence of p.P51S mutation in COCH

p.P51S mutation

Jessa Hospital

Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

presence of focal sclerosis or signal loss on CT & MR at one or more semicircular canals

video nystagmography using caloric tests ; caloric tests: °/s

video head impulse test; gain for each SCC in °/s

vestibular evoked myogenic potentials: threshold in decibel normal hearing loss (dB nHL)

tonal liminar audiometry using calibrated audiometer, threshold in dB HL

Sebastien Janssens de Varebeke

principal investigator

Vestibular test before and after hippocampal surgery
Principal criterion:
Research for an asymmetry of the vestibular responses (Caloric test, Vestibular Evoked Myogenic potentials: VEMp, Head Impulse Test: HIT, Eye Rotational Test: ERI). Investigator performs a blind vestibular test (single blind)

Epilepsy

Research of a spontaneous nystagmus with and without fixation(VIDEONYSTAGMOSCOPY) and segmentary deviations (Fukuda test)
HIT (testing semicircular canal function at high frequency).Results: Gain in %
VEMp (testing saccular function). Results: Amplitude in μV and latency in ms
ERI (testing lateral semicircular function at middle frequency). Results: Nystagmus during and after the rotations in frequency and slow phase velocity (SPV) in °/s
Caloric test (testing lateral semicircular function at low frequency). Results: Canal paresis in % and SPV in °/S

vestibular test before and after hippocampal surgery

Hôpital BEAUJON

Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery

Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Principal Investigator: Elizabeth VITTE

-Caloric test (testing lateral semicircular function at low frequency). Results: Canal paresis in % and SPV in °/S

Research of a spontaneous nystagmus with and without fixation(videonystagmoscopy) and segmentary deviations (Fukuda test)
HIT (testing semicircular canal function at high frequency). Results: Gain in %
VEMp (testing saccular function). Results: Amplitude in μV and latency in ms
ERI (testing lateral semicircular function at middle frequency). Results: Nystagmus during and after the rotations in frequency and slow phase velocity (SPV) in °/s

bilateral vestibulopathy/atrofija

Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects

Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy

Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery

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