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bruceantin/lymphoma
Povezava se shrani v odložišče
3 rezultatov
Multiple myeloma regression mediated by bruceantin.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
Bruceantin has been shown to induce cell differentiation in a number of leukemia and lymphoma cell lines. It also down-regulated c-MYC, suggesting a correlation of down-regulation with induction of cell differentiation or cell death. In the present study, we focused on multiple myeloma,
Antitumor activity of bruceantin: an old drug with new promise.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Bruceantin was first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice. Phase I and II clinical trials were then initiated, but no objective tumor regressions were
Altering chemosensitivity by modulating translation elongation.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
The process of translation occurs at a nexus point downstream of a number of signal pathways and developmental processes. Modeling activation of the PTEN/AKT/mTOR pathway in the Emu-Myc mouse is a valuable tool to study tumor genotype/chemosensitivity relationships in vivo. In this model,
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