bulbocapnine/catalepsy

The aporphine alkaloids bulbocapnine, corytuberine, boldine and glaucine were studied in mice and compared with haloperidol, phenobarbital and morphine. All aporphines inhibited the exploratory rearing activity and elicited palpebral ptosis, catalepsy, hypothermia, and prolonged anesthesia by

Role of the dopaminergic system in the cataleptogenic action of bulbocapnine.

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Prijava / prijava

Time courses of the behavioural and biochemical effects of a cataleptogenic dose (50 mg kg-1 i.p.) of bulbocapnine have been studied in the rat. Catalepsy ensues immediately after administration of the drug and lasts 1 h. Concomitant with the onset of catalepsy there is a rise in HVA and DOPAC

EGYT-2509 a novel neuroleptic agent without extrapyramidal and endocrine side effects.

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Prijava / prijava

The dibenzodioxazocine derivative EGYT-2509 was effective in neuropsychopharmacological tests characteristic for neuroleptics and antiparkinsonian drugs. It interacted with dopaminergic compounds similarly to chlorpromazine and haloperidol, but in certain tests it showed different activity.

[Genetically determined predisposition to convulsive seizures as a result of a generalized defect in catecholamine metabolism in the central nervous system].

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Prijava / prijava

The author compared the functional properties of the strial system in KM rats sensitive to the convulsive effects of sound and in Wistar rats which are insensitive to those effects. It was shown that bulbocapnine (an antagonist of dopamine) administered to the Wistar rats in a dose of 40 mg/kg body

Genetically determined predisposition to convulsions as the result of a generalized defect in the metabolism of catecholamines in the central nervous system.

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Prijava / prijava

The author compared the functional properties of the striatal system in KM rats sensitive to the convulsive effects of sound with those in Wistar rats, which are insensitive to these effects. It was shown that bulbocapnine (an antagonist of dopamine) administered to the Wistar rats at a dose of 40

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Herbal & Natural Medicine

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