carbazole/driska

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Analgesic and anti-inflammatory activity of 6-chloro-alpha-methyl-carbazole-2-acetic acid (C-5720).

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Prijava / prijava

The carbazole, C-5720, has the same order of analgesic, antipyretic and anti-inflammatory activity as indomethacin and is more potent than phenylbutazone and acetylsalicylic acid in the yeast inflamed paw, the carrageenin foot edema, the Mycobacterium butyricum-induced pyrexia, and the acute and

Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase.

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Prijava / prijava

This study compares the affects of a new non-steroidal anti-inflammatory drug, d,l-6-chloro-alpha-methyl-carbazole-2-acetic acid, its enantiomers, and indomethacin on platelet aggregation, prostaglandin synthetase, adjuvant arthritis, gastric ulceration and arachidonic acid induced diarrhea. In the

Pharmacokinetic and clinical studies of carprofen in gout.

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Prijava / prijava

Carprofen, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. After a single dose of 100 mg, plasma caprofen peaked in 1 to 2 hours, and t 1/2 was estimated to be 4.4 +/- 1.4 hours, based on a monoexponential fit of the data. Cumulative urinary excretion of total

Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.

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Prijava / prijava

New metabolites, xiamycins C-E (1-3), were isolated from a Streptomyces. sp (#HK18) culture inhabiting the topsoil in a Korean solar saltern. The planar structures of the xiamycins C-E were elucidated as carbazole-bearing indolosesquiterpenoids using a combined analysis of NMR, MS, UV, and IR

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