chymopapain/nekroza

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The response of nerve tissue to chymopapain.

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Prijava / prijava

This study was undertaken to clarify the effects of topically injected chymopapain on the spinal cord and peripheral nerves in rabbits, and also the effect of ganglioside on sciatic nerves which had been damaged by chymopapain. There were no abnormal macroscopic or microscopic findings when

Possible role of collagen in transverse myelitis and chymopapain-induced paraplegia.

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Prijava / prijava

We studied the effect of nucleus pulposus (NP) on platelet aggregation. Our in vitro experiments showed that NP extract produced platelet aggregation and the addition of collagenase to the NP extract abolished this response. It was further shown that chymopapain did not affect the activity of the

Effects of collagenase and chymopapain on spinal nerves and intervertebral discs of cynomolgus monkeys.

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Prijava / prijava

In order to test the safety and efficacy of Nucleolysin, a collagenase for intradiscal chemotherapy, laminectomies were performed on the L2-3 intervertebral discs of four groups of three young adult Cynomolgus monkeys. One primate from each group was injected with half the recommended human dose of

Selective Chemonucleolysis With Condoliase in Cynomolgus Monkeys

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Prijava / prijava

Selective chemonucleolytic effects of condoliase, a glycosaminoglycan degrading enzyme, was investigated histopathologically in cynomolgus monkeys. Condoliase was administered once into the lumber intervertebral disc (IVD), and as a comparative control, chymopapain, a proteolytic enzyme, was

Experimental model of disc herniations in rats for study of nucleolytic drugs.

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Prijava / prijava

An experimental model of disc herniation in tail discs of rats is described. Constant result on nucleus hernia and intervertebral narrowing were obtained by an easy manipulation on numerous rats. Intradiscal injection of aprotinin produced a widening of the disc height. Trypsin, collagenase,

Serial changes observed by magnetic resonance imaging in the intervertebral disc after chemonucleolysis. A consideration of the mechanism of chemonucleolysis.

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Prijava / prijava

Changes in the intervertebral disc after chemonucleolysis in 26 patients were observed by magnetic resonance imaging for 1 year, and from the results a mechanism for chemonucleolysis was considered. A reduction in size of the herniation was not recognized 2 weeks after treatment, when chymopapain

[Intradiscal injection of hypertonic saline, phenol-glycerin and osmic acid for the treatment of lumbar disc herniation: an experimental study].

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Prijava / prijava

The present study was designed to investigate the possible clinical application of hypertonic saline (HS), phenol in glycerin (PHG) and osmic acid (OSA) for intradiscal therapy. METHODS HS in several concentrations, 10% PHG and 4% OSA were separately injected into the lumbar intervertebral discs of

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