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6 rezultatov
Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly oxygenated clerodane diterpenes, were isolated from the plant Casearia arguta
The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Disobulbin-D (DBD), a hepatotoxic furano norclerodane diterpenoid, was isolated by bio-guided fractionation from the rhizome of Dioscorea bulbifera L. In working toward elucidating the cellular and molecular mechanisms of DBD toxicity, we treated normal human liver cell line L-02 cells with DBD in
Hepatotoxicity of germander in mice.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
OBJECTIVE
An epidemic of hepatitis due to germander teas or capsules recently occurred in France. The aim of the present study was to show the hepatotoxicity of germander and determine its mechanism in mice.
METHODS
A germander tea lyophilisate and a fraction that isolated and concentrated 10-fold
Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Clerodane diterpenes have demonstrated cytotoxic, antiplasmodial and anti-ulcer properties. In the present work, we determined the cytotoxic effect of casearin L (Cas L), O (Cas O) and X (Cas X) and (-)-hardwickiic acid isolated from Casearia sylvestris leaves, and investigated the underlying
Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND
Casearia sylvestris (Salicaceae) is found in South America and presents antiulcerogenic, cytotoxic, antimicrobial, anti-inflammatory and antihypertensive activities.
OBJECTIVE
To assess the in vivo and ex vivo antitumor action of a fraction with casearins (FC) and its main component -
Effect of Hautriwaic Acid Isolated from Dodonaea viscosa in a Model of Kaolin/Carrageenan-Induced Monoarthritis.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
In the present work, the antiarthritic activity of hautriwaic acid is reported. This ent-clerodane diterpene isolated from Dodonaea viscosa was evaluated in mice using a kaolin/carrageenan-induced monoarthritis model. The inflammation observed in the joint (knee) on days 1-8 ranged from 50-70 %.
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