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clitoria/protease

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ČlankiKliničnih preskušanjPatenti
3 rezultatov

The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity.

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Prijava / prijava
Plant asparaginyl endopeptidases (AEPs) are expressed as inactive zymogens that perform maturation of seed storage protein upon cleavage-dependent autoactivation in the low-pH environment of storage vacuoles. The AEPs have attracted attention for their macrocyclization reactions, and have been
Aedes aegypti, the principal mosquito vector of yellow fever, dengue fever and chikungunya fever virus-transmitted diseases, is an insect closely associated with humans and their housing habitats. As there is no commercially available vaccine, prevention is the most suggested form of avoiding

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis.

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Prijava / prijava
Proteases are ubiquitous in nature, whereas naturally occurring peptide ligases, enzymes catalyzing the reverse reactions of proteases, are rare occurrences. Here we describe the discovery of butelase 1, to our knowledge the first asparagine/aspartate (Asx) peptide ligase to be reported. This highly
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