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colonic polyps/tyrosine

Povezava se shrani v odložišče
ČlankiKliničnih preskušanjPatenti
14 rezultatov
OBJECTIVE To examine the changes that occur in the immunohistochemistry of vasoconstrictor and vasodilator transmitters in nerves supplying early and advanced colorectal polyps. METHODS We studied the perivascular innervation of submucosal arterioles of colorectal polyps (n = 18) and the innervation

Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Lemur tyrosine kinase-3 (LMTK3) belongs to the family of serine-threonine-tyrosine kinases and the aberrant expression of LMTK3 was observed in several human malignancies. However, the association of LMTK3 with clinical outcomes in colorectal cancer patients is unclear. Thus, this present study was
RT-PCR was used to examine the expression of LAR (encoding the leukocyte-common antigen-related protein tyrosine phosphatase) in normal human colon mucosa, and colon polyps and tumors. Although the LAR protein was not detected in the colon in a previous immunohistochemical study, amplification of a

Receptor tyrosine kinases expressed in metastatic colon cancer.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Using a PCR-based cloning technique, we have isolated a series of DNA fragments coding for tyrosine kinases that are expressed in a metastatic human colon tumor, and have subsequently analyzed their expression pattern at the protein level in human tumors. We identified both the alpha and the beta
Colon cancer prevention currently relies on colonoscopy using white light to detect and remove polyps, but small and flat polyps are difficult to detect and frequently missed when using this technique. Fluorescence colonoscopy combined with a fluorescent probe specific for a polyp biomarker may

Genetic basis of cancer of the kidney: disease-specific approaches to therapy.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Studies during the past two decades have shown that kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in this organ. Clear cell renal carcinoma is characterized by mutation of the VHL gene. The VHL gene product forms a heterotrimeric complex
Leptin plays a key role regulating food intake, body weight and fat mass. These critical parameters are associated with an increased risk for digestive and mammary gland cancer in the Western population. Here we determined whether leptin contributes to the invasive phenotype of colonic and kidney

Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Prophylactic vaccination is typically utilized for the prevention of communicable diseases such as measles and influenza but, with the exception of vaccines to prevent cervical cancer, is not widely used as a means of preventing or reducing the incidence of cancer. Here, we utilize a peptide-based

[News in management of colorectal cancer at JFHOD 2012 meeting].

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
All aspects of the management of colorectal cancer were presented during the 2012 edition of JFHOD meeting, from screening to new drugs tested in metastatic situation. It was confirmed that an average number of more than 0.8 detected polyps was a quality criteria of screening colonoscopies performed
A selective KGFR tyrosine kinase inhibitor, N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide, was synthesized and its possible inhibitory effects on the development of colon polyps and colorectal tumors was examined in APC(Min/+) mice, a mouse model of human intestinal familial adenomatous

Birt-Hogg-Dubé syndrome: a novel marker of kidney neoplasia.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND Birt-Hogg-Dubé syndrome (BHD) is a dominantly inherited predisposition for development of fibrofolliculomas, trichodiscomas, and acrochordons. Concurrent internal tumors, such as colonic polyps and renal carcinoma, have been described in patients with BHD. OBJECTIVE To evaluate kindreds

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Colonic neoplasia provides an opportunity to study tumor progression because most carcinomas arise from adenomas (polyps), which, in turn, arise from normal epithelia. The malignant potential of adenomas varies with size, histology, and degree of dysplasia. Polyps that are less than 2 cm with

The COOH-terminal Src kinase Csk is a tumor antigen in human carcinoma.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The cytoplasmic tyrosine kinase cSrc is involved in the regulation of many important cellular functions including cell growth and transformation, and its activity is down-regulated by phosphorylation of the Tyr530 residue by the COOH-terminal Src tyrosine kinase, Csk. Because cSrc was previously

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Activation of the tyrosine kinase of the c-src gene product, pp60c-src, has been shown to occur in nearly every primary colorectal carcinoma, and is found as early as in polyps of high malignant potential. However, no studies have addressed potential pp60c-src changes which occur during progression.
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