corneal ulcer/tyrosine

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Soluble tyrosine aminotransferase deficiency: an unusual cause of corneal ulcers.

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Tyrosine kinase inhibitor-induced corneal ulcers.

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Crystals in corneal epithelial lesions of tyrosine-fed rats.

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Prijava / prijava

Tyrosine-fed rats develop corneal disease which mimics that found in the human metabolic disorder, tyrosinosis. By electron and polarizing microscopy needle-shaped birefringent crystals are demonstrable in early corneal epithelial lesions of tyronsine-fed rats. The crystals appear as negative images

Perforating corneal ulceration in a patient with lung metastatic adenocarcinoma treated with gefitinib: a case report.

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Prijava / prijava

We present a case of a sixty-year-old female who presented with sudden onset of painless loss of vision in one eye due to a perforated corneal ulcer, following three months of treatment with gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for metastatic

The role of NGF signaling in human limbal epithelium expanded by amniotic membrane culture.

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OBJECTIVE Amniotic membrane (AM) transplantation facilitates rapid epithelialization in severe neurotrophic corneal ulcers. To elucidate its action mechanism, we investigated the expression of ligands and receptors of the neurotrophin family by human limbal epithelial (HLE) cells expanded on AM

An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium.

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Prijava / prijava

Normal and abnormal processes of cellular invasion often are initiated by degradation of basement membranes. The process of corneal ulceration might operate via similar mechanisms; degradation of the corneal stroma is not seen until after the basement membrane underlying the corneal epithelium in

A case of acquired trichomegaly following treatment with erlotinib.

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A woman on erlotinib treatment for lung cancer presented with a corneal ulcer from aberrant eyelash touch. She developed coarse, hyperpigmented and irregular eyelash and eyebrow growth a few months following treatment. She was treated successfully with epilation, eyelash trimming, lid hygiene and

Nitisinone-Induced Keratopathy in Alkaptonuria: A Challenging Diagnosis Despite Clinical Suspicion.

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Prijava / prijava

Alkaptonuria is a rare disorder of amino acid metabolism that causes premature large joint and spine arthropathy and cardiac valvular disease. It is characterised by elevated levels of homogentisic acid. Nitisinone (NTBC) is a benzoylcyclohexane-1,3-dione that reversibly inhibits the activity of the

Richner-Hanhart's syndrome: new ultrastructural observations on skin lesions of two cases.

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New ultrastructural observations are described in skin lesions of two brothers with Richner-Hanhart's syndrome (RHS). Physical examination of the two patients showed painful skin lesions of palms and soles combined with denderitic corneal ulceration and mental retardation. The diagnosis of RHS was

[Tyrosinemia type II. Case report].

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Tyrosinemia type II or Richner-Hanhart syndrome is a rare hereditary disease characterized by the association of pseudoherpetiform corneal ulcerations and palmoplantar hyperkeratosis. We report the case of a 12 year-old young man presenting a superficial punctate keratitis and a corneal dystrophy in

Tyrosinemia II: lessons in molecular pathophysiology.

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Prijava / prijava

Tyrosinemia II is caused by a deficiency of hepatic tyrosine aminotransferase. With the deficiency of this key enzyme of tyrosine catabolism there is an increase in plasma tyrosine and then an increase in tyrosine metabolites in the urine. The increased plasma tyrosine causes tyrosine to crystallize

[The metabolic basis of the hyperphenylalaninemias and tyrosinemia].

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Prijava / prijava

The hyperphenylalaninemias are caused by the defect of either phenylalanine hydroxylase (PAH) or tetrahydrobiopterin (BH4) cofactor. The former is diagnosed as phenylketonuria (PKU) or benign hyperphenylalaninemia, based on the serum phenylalanine values. The latter, so called malignant

Erlotinib-related keratopathy in a patient underwent laser in situ keratomileusis.

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Prijava / prijava

Erlotinib is a tyrosine kinase inhibitor of the epidermal growth factor receptor. Since there is a wide expression of the epidermal growth factor receptors in the epithelial tissues of ocular surface and adnexa, ocular adverse reactions may happen during systemic administration of erlotinib.

Host-parasite interactions in Staphylococcus aureus keratitis.

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Prijava / prijava

Ulcerative keratitis is among the leading ocular bacterial infections, and Streptococcus aureus accounts for approximately 25% of cases in some surveys. Although S. aureus expresses numerous virulence factors, many of which are under the control of staphylococcal global regulatory genes, their

Spontaneous healing of corneal perforation after temporary discontinuation of erlotinib treatment.

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OBJECTIVE To report a case of corneal perforation associated with oral administration of erlotinib and its spontaneous healing after temporary discontinuation of drug treatment. METHODS A 65-year-old man with metastatic lung cancer was treated with erlotinib (150 mg/day), a specific tyrosine kinase

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