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8 rezultatov
[Natural carcinogens: toxicity and carcinogenicity of cyasin: induction of tumors by cycasin in the seeds of Cycas revoluta].
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Prijava / prijava
Diet and nutrition as risk factors for cancer.
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Prijava / prijava
Involvement of diet and nutrition as risk factors for human cancers has been established by two general types of evidence. Epidemiological studies in human populations have identified associations between patterns of incidence for various forms of cancer and diet composition or food consumption
Tumor incidence in a chemical carcinogenesis study of nonhuman primates.
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Prijava / prijava
This report covers a 32-year period of an ongoing chemical carcinogenesis study in nonhuman primates, which was initiated by the National Cancer Institute in 1961. Autopsy records of 373 breeders and normal controls showed very low incidence of spontaneous malignant tumors in cynomolgus (1.5%) and
[Histology, fine structure and differentiation of experimental Wilms tumors (author's transl)].
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Prijava / prijava
Histologic studies indicate that the cycasin-induced Wilms' tumor in the rat is equal to human nephroblastoma in appearance. Therefore, it may represent an interesting system for experimental oncology. In electron microscopy, the spindle cells of the sarcoma region mostly represent tubular cells.
Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators?
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Prijava / prijava
Recognition of overlapping molecular signaling activated by a chemical trigger of cancer and neurodegeneration is new, but the path to this discovery has been long and potholed. Six conferences (1962-1972) examined the puzzling neurotoxic and carcinogenic properties of a then-novel toxin [cycasin:
Dietary protein and chronic toxicity of 1,2-dimethylhydrazine fed to mice.
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Prijava / prijava
1,2-Dimethylhydrazine-HCl (DMH-2HCl) is derived from the natural toxin cycasin, and is extensively used to induce cancers in experiments with rodents. We examined the toxicity of DMH-2HCl, incorporated into purified diets varying in protein, to determine concentrations compatible with long-term
Acute Cycas seed poisoning in Taiwan.
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Prijava / prijava
OBJECTIVE
The seeds of cycads contain cycasin and neocycasin, which belong to the family of cyanogenic glycosides. These glycosides of cycads are considered pseudocyanogenic with little potential to liberate hydrogen cyanide as other cyanogenic glycosides do. This study investigated the clinical
Intestinal microflora: metabolism of drugs and carcinogens.
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Prijava / prijava
The intestinal microflora are capable of performing a wide variety of metabolic transformations. The digestive tract can be exposed to orally ingested, bile excreted, or blood-borne exogenous and endogenous substances that can be converted by the intestinal flora into carcinogens, mutagens,
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