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daurisoline/epileptični krč
Povezava se shrani v odložišče
3 rezultatov
Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e by 48 +/- 5% in the infusion area and
Intrasynaptosomal free calcium and nitric oxide metabolism in central nervous system oxygen toxicity.
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Prijava / prijava
BACKGROUND
Central nervous system (CNS) oxygen (O2) toxicity is complex, and the etiology of its most severe manifestation, O2 convulsions, is yet to be determined. A role for nitric oxide (NO) has been proposed, although recent data have indicated that NO is synthesized from L-arginine by an
Exploration of P-type Ca2+ channels as drug targets for the treatment of epilepsy or ischemic stroke.
Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
We investigated the neuroprotective efficacy of the P-type Ca2+ channel antagonist daurisoline against electroshock-induced convulsions in rats and mice, hypoxic/hypoglycemic-induced damage in rat hippocampal slices and brain damage induced by occlusion of the middle cerebral artery (MCA) in rats.
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