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Changes in colchicine and demecolcine content during vegetation period of colchicum autumnale L.

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Prijava / prijava

Colchicine and demecolcine were determined in raw and dried leaves, stems, mother and daughter corms of Colchicum autumnale L. in four stages of its ontogenesis. The colchicine content in raw material varies during plant growth. The content of both alkaloids decreases with drying. The HPLC method

Transformation of alkaloids of the Colchicine type in leaves and flowers of Colchicum autumnale and C. byzantinum.

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Prijava / prijava

It was found that the so far described variations in the content of colchicine alkaloids in leaves and flowers of Colchicum autumnale L. and C. byzantinum Ten. are due to enzymatic O-demethylation and degradation of colchicine (I), N-deacetyl-N-formylcolchicine (XI), and demecolcine (XVII) during

Histopathological study of experimental acute poisoning of cattle by autumn crocus (Colchicum autumnale L.).

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Prijava / prijava

Crude or dehydrated bulbs of autumn crocus (Colchicum autumnale L.) were fed to eleven calves. All the calves developed severe diarrhea and died or euthanized within 63 hr. At necropsy, the gastro-intestinal mucosa was edematous and hemorrhagic. Histologically, necrosis and degeneration with

Microsome-mediated transformation of O-methylandrocymbine to demecolcine and colchicine.

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Prijava / prijava

Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O2. In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and

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