diabetic angiopathies/kalij

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Magnesium and potassium supplementation in the prevention of diabetic vascular disease.

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Prijava / prijava

Vascular disease underlies many of the complications of diabetes and includes coronary, cerebral, renal, peripheral and retinal vascular abnormalities. Magnesium (Mg) and potassium (K) deficiencies occur frequently in diabetic patients. Because of the vasoconstrictive effects of hypomagnesemia and

Impaired hypoxic coronary vasodilation and ATP-sensitive potassium channel function: a manifestation of diabetic microangiopathy in humans?

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Prijava / prijava

[Assesment of lower extremities ischemic disease by thallium 201 perfusion scintigraphy in patients with diabetic angiopathy].

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Prijava / prijava

OBJECTIVE Tibial perfusion in diabetic microangiopathy is considered to be a diagnostic problem. A special place in quantifying muscle microcirculatory perfusion belongs to thallium 201 muscle perfusion scintigraphy (201T1 PS). Thallium, showing the characteristics of potassium (K+), enters a cell

Role of BK(Ca) channels in diabetic vascular complications.

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Prijava / prijava

OBJECTIVE This review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications. METHODS Relevant articles published in English or Chinese from 1981 to present were selected from PubMed. The search terms were "BKCa channels" and

Diabetic microangiopathy and urinary glycosaminoglycans.

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Prijava / prijava

Alterations in the metabolism of glycosaminoglycans (GAG) may play a role in the pathogenesis of diabetic-associated microangiopathy. Consequently, the relationship between diabetic nephropathy and retinopathy and urinary GAG distribution was assessed in 96 IDDM patients in comparison to 103 healthy

Reduced plasma aldosterone concentrations in randomly selected patients with insulin-dependent diabetes mellitus.

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Abnormalities of the renin-angiotensin system have been reported in patients with diabetes mellitus and with diabetic complications. In this study, plasma concentrations of prorenin, renin, and aldosterone were measured in a stratified random sample of 110 insulin-dependent (Type 1) diabetic

Up-regulation of intracellular signalling pathways may play a central pathogenic role in hypertension, atherogenesis, insulin resistance, and cancer promotion--the 'PKC syndrome'.

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Prijava / prijava

The modern diet is greatly different from that of our paleolithic forebears' in a number of respects. There is reason to believe that many of these dietary shifts can up-regulate intracellular signalling pathways mediated by free intracellular calcium and protein kinase C, particularly in vascular

Diabetes and vascular disease: functional alterations in adrenergic neurotransmission and endothelium.

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Prijava / prijava

Diabetes is characterized by hyperglycemia, a relative lack of insulin, and an inclination to vascular disease and neuropathy. The link between diabetes and vascular disease is not understood, but autonomic dysfunction could partly account for alterations in reactivity of diabetic blood vessels to

Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus.

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Prijava / prijava

1. An increase in capillary blood flow and pressure has been implicated in the pathogenesis of diabetic microangiopathy. Abnormal vascular reactivity of the resistance vasculature may play a contributory role by permitting alterations in regional haemodynamics. 2. We have studied the contractile

COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.

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Prijava / prijava

OBJECTIVE Abnormalities in vascular constriction and dilatation are associated with early diabetes and contribute to diabetic vascular complications. However, mechanisms underlying such vascular dysfunction remain to be fully elucidated. The current study tests the role of cyclooxygenase-2 (COX-2)

Gliclazide modified release: A critical review of pharmacodynamic, metabolic, and vasoprotective effects.

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Prijava / prijava

Gliclazide modified release (MR) is a new formulation of the drug gliclazide and is given once daily. The specifically designed hydrophilic matrix of gliclazide MR leads to a progressive drug release that parallels the 24-hour glycemic profile in type 2 diabetic patients. Development studies showed

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