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diabetic foot/tyrosine

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ČlankiKliničnih preskušanjPatenti
7 rezultatov
Diabetic foot ulcer (DFU) is one of the most devastating diabetic consequences leading to amputations. Oxidative stress, inflammation, vascular insufficiency and neuropathy have been linked to DFU development. Since soluble fms-Like Tyrosine Kinase-1 (sFlt-1) is one of the

Effect and Mechanism of the Bruton Tyrosine Kinase (Btk) Inhibitor Ibrutinib on Rat Model of Diabetic Foot Ulcers.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
BACKGROUND Diabetes causes damage to the soft tissue and bone structure of the foot, referred to as "diabetic foot". Ibrutinib is a Bruton tyrosine kinase (Btk) inhibitor, and the role and mechanism of ibrutinib on the diabetic foot have not been elucidated. MATERIAL AND METHODS Male
One of the common complications diagnosed in Diabetes Mellitus (DM) patients is Diabetic Foot Ulcers (DFUs). It is a condition wherein the deep tissues located in the lower limb undergo inflammation and infection due to neurological abnormalities (neuropathy) and various degrees of vascular diseases

Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes

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Prijava / prijava
Non-healing diabetic foot ulcers (DFUs) are a serious complication in diabetic patients. Their incidence has increased in recent years. Although there are several treatments for DFUs, they are often not effective enough to avoid amputation. Protein tyrosine phosphatase 1B (PTP1B) is expressed in

Mechanisms involved in the development and healing of diabetic foot ulceration.

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Prijava / prijava
We examined the role of vascular function and inflammation in the development and failure to heal diabetic foot ulcers (DFUs). We followed 104 diabetic patients for a period of 18.4 ± 10.8 months. At the beginning of the study, we evaluated vascular reactivity and serum inflammatory cytokines and

Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome.

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Prijava / prijava
Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid,

Neurotrophic factors and their receptors in human sensory neuropathies.

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Prijava / prijava
Neurotrophic factors may play key roles in pathophysiological mechanisms of human neuropathies. Nerve growth factor (NGF) is trophic to small-diameter sensory fibers and regulates nociception. This review focuses on sensory dysfunction and the potential of neurotrophic treatments. Genetic
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