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eburnamonine/ishemija

Povezava se shrani v odložišče
ČlankiKliničnih preskušanjPatenti
9 rezultatov
The effect of (-)eburnamonine, papaverine and UDP-glucose intracarotid perfusion has been evaluated in the brain of beagle dogs during various conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischaemia, hypoxia plus complete ischaemia), and after 3, 15 or 30 min of the post-hypoxic
The activity of (-)eburnamonine, a substance acting on the cerebral circulation and metabolism, was compared with that of nicergoline in a double-blind study carried out on a group of 28 patients (16 males and 12 females), suffering from established chronic brain ischemia. The treatment consisted of

[Open clinical trial with (-)eburnamonine in patients suffering from cerebral ischemia].

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava

Medical therapy of cerebral ischemia. Vasoactive and eumetabolic therapy.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
After briefly evaluating the contraindications and indications of vasoactive and eumetabolic therapy of cerebral ischemia, the paper considers the main drugs at present in use in therapy of the syndrome induced by diffused cerebral arteriosclerosis. Among the drugs with a mainly vasoactive effect,
With the purpose to define the specific activity of substances acting on the cerebral circulation and metabolism, (-)eburnamonine and cinnarizine were compared in a double-blind study carried out in a group of 106 elderly patients suffering from established chronic brain ischemia. The

Retinal angiography in the study of cerebral ischemia.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
On the basis of the assumption of an affinity between cerebral and retinal vessels, it was sought to demonstrate that the variations induced in the retinal circulation are akin to those occurring at the cerebral level. The technique of retinal fluorescein angiography was used to evaluate the

Drug action on cerebral energy state during and after various hypoxic conditions.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
The behaviour of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), as well as the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge of the brain were studied in the motor area of the cerebral

Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice.

Samo registrirani uporabniki lahko prevajajo članke
Prijava / prijava
Vinpocetine has been compared with 3 structurally related drugs for activity in protecting mice from hypoxia-induced lethality upon i.p. administration. In order of potency, vinpocetine (ED50 = 16.6 mg/kg), 1-eburnamonine (ED50 = 21.0 mg/kg), vinconate (ED50 approximately 25 mg/kg), and vincamine
The effects of a new eburnamenine derivative (3 beta,14 alpha, 16 alpha)-(+/-)-14,15-dihydro-20,21-dinoreburnamenin-14-ol (vindeburnol, RU 24722) on EEG, on brain energy metabolism and on local cerebral blood flow (LCBF) and in different experimental models of cerebral insufficiency were compared
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