hypospadias/tyrosine

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Novel amino acid substitutional mutation, tyrosine-739-aspartic acid, in the androgen receptor gene in complete androgen insensitivity syndrome.

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Prijava / prijava

Androgen insensitivity syndrome (AIS) is an X-linked recessive disorder. The molecular mechanism of AIS is reduction or absence of androgen signalling caused by androgen receptor (AR) malfunction or absence. The phenotype of AIS varies from a complete female phenotype (complete AIS, CAIS) to male

Severity-Dependent Profile of the Metabolome in Hypospadias.

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Prijava / prijava

Background & Objective: Hypospadias, characterized by the displacement of the opening of the urethra at any point in the medial-ventral side of the penis, is classified upon severity as mild (Type I) and severe (Type II and Type III) hypospadias. Hypospadias' etiology is idiopathic in the

[Pregnancy outcome among patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors].

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Prijava / prijava

OBJECTIVE To observe the pregnancy outcome among patients with chronic myelogenous leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). METHODS Data associated with pregnancy, delivery and neonate from the patients or patient's spouse who conceived while receiving TKIs were collected

[Fertility and disease outcomes in patients with chronic myeloid leukemia].

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Prijava / prijava

Objective: To explore Fertility and disease outcomes in patients with chronic myeloid leukemia (CML) . Methods: Clinical and fertility outcomes of male (from Jul. 1998 to Feb. 2018) and female CML (from Sep. 2009 to Feb. 2018) patients were retrospectively analyzed at Peking University

Conditional deletion of platelet derived growth factor receptor alpha (Pdgfra) in urorectal mesenchyme causes mesenchyme apoptosis and urorectal developmental anomalies in mice.

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Prijava / prijava

In mammals, urorectal development starts at early embryonic stage, defective urorectal development results in anorectal malformations, which are common congenital developmental defects of the anus and the urethra in newborns. The etiology and embryology of the defects are still largely unknown.

Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring.

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Prijava / prijava

We have previously demonstrated that male rats exposed to stress during the last week of gestation present age-specific impairments of brain development. Since the organization of the fetal developing brain is subject to androgen exposure and prenatal stress was reported to disrupt perinatal

Molecular effects of genistein on male urethral development.

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Prijava / prijava

OBJECTIVE The increasing incidence of hypospadias is partly attributed to increased gestational exposure to endocrine disruptors. We investigated the effects of genistein, the primary phytoestrogen in soy, on the molecular program of male urethral development. METHODS Female mice were fed diets

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Herbal & Natural Medicine

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