isoharringtonine/cephalotaxus

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[Isoharringtonine induces apoptosis in human leukemia HL-60 cell].

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Prijava / prijava

Harringtonine (HT), homoharringtonine (HHT) and isoharringtonine (IHT) are cephalotaxine alkaloids with anticancer activities which were isolated from Cephalotaxus hainanensis indigenous to China. Since the 1970s, HT and HHT have been developed as effective anticancer drugs in China and have been

HPLC-electrospray ionization-MS-MS analysis of Cephalotaxus harringtonia leaves and enhancement of the extraction efficiency of alkaloids therein by SFE.

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Prijava / prijava

A high-performance liquid chromatographic method is developed for use in the electrospray mass spectrometric (MS)-MS analysis of alkaloids contained in Cephalotaxus harringtonia leaves. Nine alkaloids having ester groups can be separated and detected with good sensitivity. The MS and MS-MS spectra

[Studies on the alkaloids of Cephalotaxus. VII. Structures and semi-synthesis of two anticancer cephalotaxine esters].

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Prijava / prijava

Two new alkaloids, namely neoharringtonine (1) and anhydroharringtonine (2) with significant antileukemic activity were isolated from Cephalotaxus fortunei Hook f.. Their structures have been established by spectral analyses and semi-synthesis. Seven known alkaloids, deoxyharringtonine (3),

[Studies on the alkaloids of Cephalotaxus. IX. Semi-synthesis of cephalotaxine esters and their anti-leukemic activity].

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Prijava / prijava

Harringtonine, homoharringtonine, deoxyharringtonine and isoharringtonine isolated from Cephalotaxus plant are the esters of cephalotaxine with significant inhibitory activity against P-388 leukemia. In this investigation seventeen new esters of cephalotaxine type alkaloids have been synthesized.

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