keratosis/utrujenost

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Evaluation of the Use of Capecitabine for the Treatment and Prevention of Actinic Keratoses, Squamous Cell Carcinoma, and Basal Cell Carcinoma: A Systematic Review

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Prijava / prijava

Importance: Certain patient groups, such as solid organ transplant recipients (SOTRs), have a significantly increased risk of developing skin cancers. The chemotherapeutic drug capecitabine has been used off label as a chemopreventive

A case of vemurafenib-induced keratosis pilaris-like eruption.

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Prijava / prijava

Vemurafenib, a selective BRAF kinase inhibitor, is a new anti-cancer drug recently proven to improve survival in patients with metastatic melanoma harboring the BRAF V600E mutation. BRAF is one of three RAF kinases (ARAF, BRAF, CRAF) involved in the MAP kinase pathway. Mutations in BRAF are reported

Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib.

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Prijava / prijava

BACKGROUND Sorafenib-induced dermatologic toxicity is common and consists primarily of dry skin, maculopapular rash, hand-foot skin reaction, and alopecia. Cutaneous squamous cell carcinoma (SCC) and inflammation of actinic keratosis (AK) were reported in 2 patients treated with sorafenib (Lacouture

Life-Threatening Reaction with Topical 5-Fluorouracil.

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Prijava / prijava

A 67-year-old man developed a suspected adverse drug reaction during treatment with topical 5-fluorouracil (5-FU) for multiple actinic keratosis of the face, neck, and forearms. The man received topical 5-FU at a dosage of 0.5% for the actinic keratoses. After 1 week, he developed extreme lethargy,

Systemic toxicity to betamethasone ointment

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Prijava / prijava

Topically applied betamethasone for actinic keratosis may trigger systemic side effects. Systemic side effects of topical betamethasone may completely resolve after discontinuation of the causative agent. A 59-year-old male patient with scalp actinic keratosis developed fatigue and the need to sleep

Topical Imiquimod Induces Severe Weakness and Myalgias After Three Applications: A Case Report.

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Prijava / prijava

Imiquimod can be used to treat superficial basal cell carcinoma, actinic keratosis, genital warts, and other skin conditions. The adverse events associated with this topical agent commonly include application site irritation, primarily erythema, as well as headache, myalgia, and fatigue. There are

Porphyria cutanea tarda: a case report.

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Prijava / prijava

The porphyrias are a rare group of metabolic disorders that can either be inherited or acquired. Along the heme biosynthetic pathway, porphyrias can manifest with neurovisceral and/or cutaneous symptoms, depending on the defective enzyme. Porphyria cutanea tarda, the most common type

Efficacy and tolerability of vemurafenib in patients with BRAF(V600E) -positive papillary thyroid cancer: M.D. Anderson Cancer Center off label experience.

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Prijava / prijava

BACKGROUND Vemurafenib, a selective BRAF inhibitor, appears to have promising clinical activity in patients with papillary thyroid cancer (PTC) harboring the BRAF(V600E) mutation. OBJECTIVE To determine the efficacy and safety of vemurafenib when used outside of a clinical trial. METHODS A

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