kolaflavanone/garcinia

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Experimental and computational modeling of interaction of kolaviron-kolaflavanone with aldehyde dehydrogenase.

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Prijava / prijava

Aldehyde dehydrogenases (ALDHs) are a diverse family of enzymes that catalyze the NAD(P)+-dependent detoxification of toxic aldehyde compounds. ALDHs are also involved in non-enzymatic ligand binding to endobiotics and xenobiotics. Here, the enzyme crucial non-canonical and non-catalytic interaction

Fingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines.

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Prijava / prijava

African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ensuring the health of population and in order to advance towards improved traditional medicines

Antihepatoxic constituents of Garcinia kola seeds.

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Prijava / prijava

Kolaviron, a fraction of defatted methanolic extract and biflavanones of Garcinia kola seeds significantly antagonized the lethal poisoning of mice with phalloidin. Garcinia biflavanones GB1, GB2 and kolaflavanone were isolated as the active constituents.

Study on characteristics of biflavanones distribution in Garcinia kola seeds and identification of compounds in gum resin exuded from fresh slices

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Prijava / prijava

Garcinia kola seeds play an important role in African traditional medicine, which are widely used to treat stomachache, gastritis, malaria, venereal diseases and laryngitis. The habitats, specification, different parts of seeds and slicing process are important factors that affect the quality of

Capillary electrophoresis determination of biflavanones from Garcinia kola in three traditional African medicinal formulations.

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Prijava / prijava

A rapid capillary electrophoresis (CE) method for the quantification of four biologically active biflavanones present in three different traditional African medicinal preparations from the seeds of Garcinia kola was developed. The four biflavanones of interest (GB1, GB2 and GB1-glycoside and

Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats.

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Prijava / prijava

1. The hypolipidaemic effect of kolaviron, a mixture of Garcinia biflavonoid 1 (GB1), Garcinia biflavonoid 2 (GB2) and kolaflavanone, used in the treatment of various ailments in southern Nigeria, was investigated in rats. The ability of Questran (Bristol-Myers Squibb, Hounslow, UK), a

Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract.

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Prijava / prijava

The effect of kolaviron, a mixture of Garcinia biflavonoid 1 (GB1), Garcinia biflavonoid 2 (GB2) and kolaflavanone, used in the treatment of various ailments in southern Nigeria on hepatotoxicity and lipid peroxidation induced by 2-acetylaminofluorene (2-AAF) in rats was investigated. The ability of

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